Table 1.

Characteristics of target study populations

Study (Array)CharacteristicsCasesControlsPdifference
HNSCC (27K)Total samples9292
mdNLR, mean (SD)3.0 (1.6)1.7 (0.7)1.2 × 10−10
Age, median years (range)58 (31–84)59 (32–86)0.54a
Gender0.99b
 Male64 (70%)64 (70%)
 Female28 (30%)28 (30%)
Race0.99b
 White84 (91%)85 (92%)
 Nonwhite8 (9%)7 (8%)
Smoking history0.04b
 Never17 (19%)32 (35%)
 Former59 (64%)47 (51%)
 Current16 (17%)13 (14%)
HPV16 (E6, E7, or L1)0.0002b
 Negative66 (72%)83 (90%)
 Positive26 (28%)9 (10%)
Tumor site
 Laryngeal18 (20%)N/A
 Oral cavity47 (50%)N/A
 Oropharyngeal25 (27%)N/A
Bladder cancer (27K)Total samples223237
mdNLR, mean (SD)2.6 (1.9)2.8 (2.2)0.33
Age, median years (range)66 (25–74)65 (28–74)0.05a
Gender0.06b
 Male171 (77%)158 (67%)
 Female52 (23%)79 (33%)
Race0.99b
 White223 (100%)237 (100%)
 Nonwhite
Smoking history<0.001b
 Never40 (18%)72 (30%)
 Former111 (50%)126 (53%)
 Current72 (32%)39 (16%)
Tumor stage
 T0a156 (70%)N/A
 Tis6 (2.7%)N/A
 T137 (17%)N/A
 T212 (5.4%)N/A
 T36 (2.7%)N/A
 T46 (2.7%)N/A
Ovarian cancer (27K)Total samples266274
 Pretreatment cases131 (49%)N/A
 Posttreatment cases135 (51%)N/A
mdNLR, mean (SD)3.15 (2.24)2.08 (1.01)2.2 × 10−16a
Age group3.7 × 10−6b
 50–5534 (13%)14 (5%)
 55–6047 (18%)68 (25%)
 60–6542 (16%)67 (24%)
 65–7043 (16%)39 (14%)
 70–7550 (19%)66 (24%)
>7550 (19%)20 (7%)
Histology
 Serous150 (56%)N/A
 Endometrioid34 (13%)N/A
 Mucinous30 (11%)N/A
 Clear cell25 (9%)N/A
 Other27 (10%)N/A
Breast Twin Study (450K)Total samples1515
mdNLR, mean (SD)2.7 (1.4)2.4 (1.2)0.08c
Healthy aging study (450K)Total656
mdNLR, mean (SD)3.0 (5.6)d
Age, median years65 (19–101)
Race
 Caucasian - European426 (65%)
 Hispanic - Mexican230 (35%)
Gender
 Female338 (52%)
 Male318 (48%)
  • aWilcoxon rank-sum test for a difference between cases and control.

  • bFisher's exact or χ2 test for a difference between cases and controls.

  • cOne-sided paired t test to assess difference in cases and controls.

  • dAverage and SD driven up by several large mdNLR outlier values in the data.