Table 4.

HRs for associations between alcohol consumption and the risk of colorectal cancer for DNA MMR gene germline mutation carriers by cancer site

ColonaRectumb
Multivariable modelcMultivariable modelc
CasesPerson-yearsHR (95% CI)PCasesPerson-yearsHR (95% CI)P
Average daily ethanol intake from any alcoholic beverage
 Abstainer15712,455.51 (Reference)359,002.51 (Reference)
 Ever user41023,0481.76 (1.27–2.46)0.0016915,7410.79 (0.41–1.53)0.49
  >0–≤14 g25214,459.51.78 (1.27–2.49)0.0013810,1230.79 (0.39–1.59)0.50
  >14 g–≤28 g754,338.51.51 (0.91–2.49)0.11102,8620.51 (0.19–1.40)0.19
  >28 g834,2501.94 (1.19–3.18)0.01212,7561.14 (0.45–2.89)0.79
   Average daily ethanol intake from any alcoholic beverage (per 14 g/day)56735,503.51.01 (0.94–1.09)0.7610424,743.51.08 (0.88–1.31)0.47
Average daily ethanol intake from beerd
 Abstainer27520,7051 (Reference)5115,2451 (Reference)
 Ever user32116,579.51.36 (0.97–1.91)0.085810,759.51.03 (0.60–1.78)0.91
   Average daily ethanol intake from beer (per 14 g/day)59637,284.50.99 (0.89–1.10)0.9010926,004.51.16 (0.91–1.48)0.24
Average daily ethanol intake from winee
 Abstainer38625,6711 (Reference)8217,604.51 (Reference)
 Ever user22111,959.51.09 (0.80–1.48)0.59298,6090.63 (0.29–1.36)0.24
   Average daily ethanol intake from wine (per 14 g/day)60737,630.50.79 (0.53–1.18)0.2611126,213.50.74 (0.29–1.87)0.52
Average daily ethanol intake from spiritsf
 Abstainer36224,5311 (Reference)6717,020.51 (Reference)
 Ever user23412,510.51.27 (0.93–1.73)0.13398,6150.94 (0.48–1.84)0.86
   Average daily ethanol intake from spirits (per 14 g/day)59637,041.51.11 (0.89–1.39)0.3410625,635.50.63 (0.24–1.66)0.35
  • Abbreviation: g/day, grams per day.

  • aNumber of colon cancers: 643; participants with synchronous colon and rectal cancers (n = 10) were excluded from analysis.

  • bNumber of rectal cancers: 116; participants with colorectal cancer synchronous colon and rectal cancers (n = 10) were excluded from analysis.

  • cAll multivariable models were adjusted for country (categorical, time-fixed), education (categorical, time-fixed), ascertainment (binary, time-fixed), sex (binary, time-fixed), BMI at age 20 (categorical, time-fixed), diabetes status (binary, time-varying), regular physical activity (binary, time-varying), and smoking status (categorical, time-varying).

  • dModels additionally adjusted for average daily ethanol intake from wine (binary, time-varying) and from spirits (binary, time-varying).

  • eModels additionally adjusted for average daily ethanol intake from beer (binary, time-varying) and from spirits (binary, time-varying).

  • fModels additionally adjusted for average daily ethanol intake from beer (binary, time-varying) and from wine (binary, time-varying).