Table 1.

Clinical characteristics of invasive EOC cases from the Ovarian Cancer Association Consortium analyzed for association with MSDC genetic variation

Vital status at last follow-up
Patient characteristicsAliveDeceasedTotal invasive EOC cases
n = 5,243 (48.8%)n = 5,508 (51.2%)N = 10,751
Age at diagnosis
 <50 years1,627 (59.1%)1,125 (40.9%)2,752
 50–69 years3,100 (47.4%)3,445 (52.6%)6,545
 70+ years516 (35.5%)938 (64.5%)1,454
Histology
 Serous2,765 (39.7%)4,207 (60.3%)6,972
 High-grade serous2,210 (38.2%)3,568 (61.8%)5,578
 Mucinous504 (72.1%)197 (27.9%)701
 Endometrioid1,058 (68.7%)485 (31.3%)1,543
 Clear cell529 (67.1%)260 (32.9%)789
 Mixed cell215 (56.7%)166 (43.3%)381
 Undifferentiated/poorly differentiated92 (42.6%)124 (57.4%)216
 Unknown epithelial70 (49.6%)69 (50.3%)139
Grade
 Well differentiated757 (70.5%)316 (29.3%)1,073
 Moderately differentiated1,107 (50.6%)1,079 (49.4%)2,186
 Poorly differentiated2,185 (42.4%)2,969 (57.6%)5,154
 Undifferentiated284 (46.8%)323 (53.2%)607
 Unknown583 (58.1%)419 (41.9%)1,002
Stage
 Localized1,393 (81.3%)320 (18.7%)1,713
 Regional1,314 (66.4%)665 (33.6%)1,979
 Distant2,109 (34.3%)4,034 (65.7%)6,134
 Unknown178 (55.5%)143 (44.5%)321