Table 3.

HRs for associations between alcohol consumption and the risk of colorectal cancer for DNA MMR gene germline mutation carriers

Univariable modelMultivariable modelaMultivariable modela,b
CasesPerson-yearsHR (95% CI)PHR (95% CI)PHR (95% CI)P
Average daily ethanol intake from any alcoholic beverage
 Abstainer19513,258.51 (Reference)1 (Reference)1 (Reference)
 Ever user48624,7021.47 (1.13–1.90)0.0031.49 (1.09–2.03)0.011.55 (1.11–2.15)0.01
  >0–≤14 g29415,340.51.39 (1.04–1.86)0.031.50 (1.09–2.07)0.011.56 (1.11–2.18)0.01
  >14–≤28 g874,662.51.29 (0.88–1.90)0.191.23 (0.78–1.94)0.371.25 (0.77–2.04)0.37
  >28 g1054,6991.95 (1.36–2.79)<0.0011.69 (1.07–2.65)0.021.79 (1.12–2.87)0.02
   Average daily ethanol intake from any alcoholic beverage (per 14 g/day)68137,960.51.07 (1.01–1.14)0.031.02 (0.94–1.09)0.661.02 (0.95–1.10)0.52
Average daily ethanol intake from beerc
 Abstainer33021,8641 (Reference)1 (Reference)1 (Reference)
 Ever user38518,012.51.55 (1.24–1.94)<0.0011.27 (0.94–1.73)0.111.23 (0.90–1.70)0.19
   Average daily ethanol intake from beer (per 14 g/day)71539,876.51.10 (1.02–1.19)0.011.02 (0.92–1.13)0.721.02 (0.92–1.12)0.75
Average daily ethanol intake from wined
 Abstainer47527,6731 (Reference)1 (Reference)1 (Reference)
 Ever user25312,565.50.97 (0.76–1.24)0.801.01 (0.76–1.34)0.961.06 (0.78–1.43)0.71
   Average daily ethanol intake from wine (per 14 g/day)72840,238.50.78 (0.54–1.11)0.180.79 (0.54–1.15)0.220.87 (0.61–1.24)0.45
Average daily ethanol intake from spiritse
 Abstainer43526,2041 (Reference)1 (Reference)1 (Reference)
 Ever user27713,331.51.30 (1.02–1.66)0.041.21 (0.91–1.61)0.191.27 (0.94–1.70)0.12
   Average daily ethanol intake from spirits (per 14 g/day)71239,535.51.19 (1.00–1.41)0.041.07 (0.85–1.36)0.571.15 (0.97–1.36)0.10
  • Abbreviation: g/day, grams per day.

  • aAll multivariable models were adjusted for country (categorical, time-fixed), education (categorical, time-fixed l), ascertainment (binary, time-fixed), sex (binary, time-fixed), BMI at age 20 (categorical, time-fixed), diabetes status (binary, time-varying), regular physical activity (binary, time-varying), and smoking status (categorical, time-varying).

  • bAll models were additionally adjusted for aspirin or ibuprofen intake (binary, time-fixed), multivitamin intake (binary, time-fixed), calcium intake (binary, time-fixed), and folic acid intake (binary, time-fixed).

  • cMultivariable models additionally adjusted for average daily ethanol intake from wine (binary, time-varying) and from spirits (binary, time-varying).

  • dMultivariable models additionally adjusted for average daily ethanol intake from beer (binary, time-varying) and from spirits (binary, time-varying).

  • eMultivariable models additionally adjusted for average daily ethanol intake from beer (binary, time-varying) and from wine (binary, time-varying).