Table 4.

Estimated population carrier frequency for each MMR gene, MUTYH, and the unidentified major susceptibility genes based on the mixed dominant model with age-dependent polygenic component

Gene% (95% CI)1 in (95% CI)
Unidentified major genes0.198 (0.036–1.079)504 (93–2,778)
MLH10.051 (0.039–0.068)1,946 (1,480–2,564)
MSH20.035 (0.026–0.048)2,841 (2,101–3,846)
MLH1 or MSH20.087 (0.065–0.115)1,155 (868–1,539)
MSH60.132 (0.089–0.196)758 (509–1,126)
PMS20.140 (0.094–0.208)714 (480–1,062)
Any MMR gene0.359 (0.248–0.520)279 (192–403)
MUTYH monoallelic2.214 (1.891–2.591)45 (39–53)
MUTYH biallelic0.012 (0.009–0.017)8,073 (5,881–11,080)