Table 2.

Weight change and survival: diagnosis to follow-up

% Weight change [HR (95% CI)]
Large loss (≥10%)Modest loss (5%–9.9%)Stable (−4.9%–4.9%)Modest gain (5%–9.9%)Large gain (≥10%)P LossP Gain
Colorectal cancer–specific mortality
 # Events/at risk65/23943/309136/1,46035/45332/320
 Minimally adjusteda3.82 (2.83–5.15)1.66 (1.18–2.35)Referent0.83 (0.57–1.20)1.09 (0.74–1.60)<0.00010.26
 Fully adjustedb3.20 (2.33–4.39)1.58 (1.12–2.23)Referent0.84 (0.58–1.22)0.93 (0.63–1.37)<0.00010.54
Overall mortality
 # Events/at risk104/23979/309235/1,46063/45368/320
 Minimally adjusteda3.59 (2.84–4.53)1.76 (1.36–2.27)Referent0.85 (0.64–1.12)1.33 (1.01–1.74)<0.00010.11
 Fully adjustedb3.27 (2.56–4.18)1.74 (1.34–2.25)Referent0.86 (0.65–1.14)1.20 (0.91–1.58)<0.00010.27
  • aAdjusted for age at diagnosis (continuous), gender, and race.

  • bAdjusted for age and weight at diagnosis (continuous), gender (female versus male), race/ethnicity (black, Hispanic, or Asian versus non-Hispanic white), stage (II or III versus I), grade (moderate or poorly/undifferentiated versus well differentiated), chemotherapy (not received versus received), radiotherapy (not received versus received), and cancer site (colon versus rectal).