Organization of SNP requests within consortia
| Consortium | |||||
|---|---|---|---|---|---|
| Selection of SNP | TRICL | BCAC/DRIVE/CIMBA | FOCI/OCAC | ELLIPSE/PRACTICAL | CORECT |
| Fine-mapping | 0.437 | 0.259 | 0.700 | 0.359 | 0.346 |
| Significant SNPs from existing GWAS | 0.032 | 0.465 | 0 | 0.379 | 0.598 |
| Sequencing/rare variants | 0.001 | 0.075 | 0 | 0.025 | 0.012 |
| Other GWAS studies/ethnicities | 0.072 | 0.044 | 0 | 0.128 | 0.005 |
| Candidate SNP and pathways | 0.156 | 0.012 | 0.105 | 0.056 | 0.027 |
| Correlated phenotypes | 0.083 | 0.015 | 0 | 0.051 | 0 |
| GxG or GxE interactions | 0.004 | 0.063 | 0.115 | 0 | 0.012 |
| SNPs from tumor genes | 0.053 | 0 | 0 | 0 | 0 |
| Functional and eQTL | 0.161 | 0.005 | 0.002 | 0 | 0 |
| Survival | 0 | 0.062 | 0.079 | 0 | 0 |
| SNPs within consortium | 32,464 | 88,475 | 42,921 | 67,757 | 37,397 |
Abbreviations: BCAC, Breast Cancer Association Consortium; CORECT, Colorectal Transdisciplinary Study; DRIVE, Discovery, Biology, and Risk of Inherited Variants in Breast Cancer; Ellipse, Elucidating Loci Involved in Prostate cancer Susceptibility; FOCI, Follow-up of Ovarian Cancer Genetic Association and Interaction Studies; OCAC, Ovarian Cancer Association Study; PRACTICAL, Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome; TRICL, Transdisciplinary Research in Cancer of the Lung.