Table 2.

Association of postdiagnosis weight change with breast cancer–specific and all-cause mortality

HR (95% CI)
Large loss (≥10%)Modest loss (>5%–<10%)Stable (within 5%)Modest gain (>5%–<10%)Large gain (≥10%)
HR (95% CI)
Breast cancer-related death
 # Events, at risk 503/12,950EventsNEventsNEventsNEventsNEventsN
79827731,5362647,836571,64530746
Age/race-adjusteda3.01 (2.34–3.87)1.42 (1.09–1.83)Ref.1.01 (0.76–1.34)1.14 (0.78–1.67)
Multivariableb2.13 (1.65–2.76)1.24 (0.95–1.61)Ref.1.06 (0.79–1.41)0.98 (0.67–1.44)
All-cause death
 # Events, at risk 980/12,950EventsNEventsNEventsNEventsNEventsN
1598271331,5365347,8361021,64552746
Age/race-adjusteda2.95 (2.47–3.52)1.26 (1.04–1.53)Ref.0.94 (0.76–1.17)1.11 (0.84–1.48)
Multivariableb2.24 (1.87–2.69)1.15 (0.95–1.39)Ref.0.96 (0.78–1.19)0.98 (0.74–1.31)
  • aAdjusted for age at diagnosis (categorical) and race.

  • bAdditionally adjusted for alcohol, smoking status, comorbidities, prediagnosis body mass index (categorical), stage, grade, receipt of adjuvant chemotherapy (yes/no), receipt of radiotherapy (yes/no), and tumor characteristics (ER, PR, and HER2 status).