Table 1.

Comorbidity burdena by age and cancer site

NoncancerAll sitesBladderCRCFemale breastLeukemiaLungOralProstate
Total100,000457,65926,04548,13852,17912,44776,3658,04380,087
66–69 y20,18092,3624,0367,36111,4071,89314,5581,91822,196
None66%56%52%56%65%56%39%56%66%
Moderate17%18%20%20%17%19%12%16%18%
Severe16%26%28%24%17%24%48%27%16%
70–74 y24,699113,0295,74010,03612,8702,51218,9821,99825,315
None61%50%47%51%59%51%34%52%61%
Moderate19%19%21%20%20%20%13%16%19%
Severe20%31%32%29%21%30%52%32%19%
75–79 y21,55598,6445,84810,07710,9512,62317,7811,59217,185
None54%45%43%46%54%45%32%46%55%
Moderate19%19%20%19%20%20%13%18%20%
Severe26%36%37%35%26%35%55%35%24%
80–84 y17,40979,6765,3399,6308,8242,52814,1801,2419,362
None48%40%38%42%49%42%30%43%49%
Moderate18%18%19%19%21%17%14%17%19%
Severe33%41%42%40%30%41%56%40%32%
85+ y16,15773,9485,08211,0348,1272,89110,8641,2946,029
None42%37%36%37%44%36%29%39%43%
Moderate17%17%17%17%19%15%13%17%16%
Severe42%47%47%46%37%49%57%44%41%
  • aCategories included comorbidities described in the Charlson Index and weighted for effect on noncancer mortality. None implies a “0” score for comorbidities, though this may not reflect common conditions that are not currently included in the Index. Moderate comorbidity included conditions that usually do not require physicians to adjust cancer treatment. Severe comorbidity burden refers to severe illnesses that frequently lead to organ failure or systemic dysfunction and always require adjustment of cancer treatment for survivors. See Materials and Methods for more detail.