Table 2.

Comparisons between different ALL disease subtypes and associated biologic pathwaysa

PathwayALLB-ALLHyperdiploid B-ALLTEL-AML ALL
Axon guidance√*√*√*
Protein digestion and absorption√*√*√*
Melanogenesis√*√*
Leukocyte transendothelial migration√*√*
Focal adhesion√*√*√*√*
Endometrial cancer√*
Glioma√*
Pathways in cancer√*√*√*
Tight junction√*√*
Regulation of actin cytoskeleton√*
Gap junction√*
Histidine metabolism√*
Pancreatic secretion√*
Bacterial invasion of epithelial cells√*
Metabolic pathways√*
Small-cell lung cancer√*√*
Amoebiasis√*
Valine, leucine, and isoleucine degradation√*
Purine metabolism
Sulfur metabolism√*
CAMs√*
ABC transporters√*
SNARE interactions in vesicular transport√*
Fat digestion and absorption√*
Non–small cell lung cancer√*

√Top 10 ranking KEGG pathways associated with disease status.

√*Adjusted P value based on correction for FDR using BH is smaller than 0.05.

  • aSNPs which showed association with each childhood ALL disease subtype (P < 0.001) and filtered by power calculation were included in this study. The analysis was limited to KEGG pathways where at least two genes were present in the submitted list and used a hypergeometric test to compare the submitted list to a reference of all human genes using WebGestalt v.2 (http://bioinfo.vanderbilt.edu/webgestalt/).