Table 3.

Baseline and 16-week differences in risk markers between study groups and treatment effects

Baseline geometric mean16 Weeks geometric mean% Change 16 weeksTERa (97.5% CI): intervention vs. controlPbTERa (95% CI): mainly exercise vs. dietPc
hsCRP (mg/L)
Control1.721.9916.2
Diet1.991.75−12.30.77 (0.53–1.14)0.042
Mainly exercise1.851.37−26.10.64 (0.44–0.95)<0.0010.83 (0.69–1.01)0.064
IL6 (pg/mL)
Control1.321.5315.9
Diet1.441.40−2.800.88 (0.65–1.19)0.192
Mainly exercise1.421.34−5.740.85 (0.63–1.14)0.0920.96 (0.83–1.12)0.631
Control9.168.95−2.29
Diet9.819.78−0.321.03 (0.96–1.10)0.241
Mainly exercise9.599.761.791.05 (1.03–1.18)0.0491.02 (0.98–1.06)0.313
Leptin (ng/mL)
Control26.226.51.13
Diet29.317.3−41.00.59 (0.46–0.77)<0.001
Mainly exercise31.117.10−45.10.55 (0.43–0.72)<0.0010.94 (0.82–1.07)0.351
• NOTE: Complete cases, that is, women with both baseline and follow-up measurements, are presented. Therefore, baseline values may differ from the values as presented in Table 1. Complete case data of CRP was available for n = 229 (94.2%) women, 1 woman was excluded because of an abnormal CRP value at follow-up (>25 mg/L). IL6, adiponectin, leptin, n = 231 [control, n = 44 (91.7%); diet, n = 94 (96.9%); mainly exercise, n = 93 (94.9%)].

• aTER: the treatment effect ratio (and 97.5% or 95% CI) represents the overall intervention effect on change in biomarker (adjusted for baseline biomarker level), estimated by linear regression analysis. The linear regression models were based on log-transformed biomarker data, therefore, the treatment effect is a ratio that indicates how many times the biomarker level is, on average, higher (TER>1) or lower (TER<1) in (i) the intervention group compared with the control group, or (ii) mainly exercise compared with the diet group. For example, TER = 0.9 indicates that the biomarker level in the intervention group is on average 10% lower compared with the control group.

• bP < 0.025 is considered significant for the comparison of both intervention groups vs. control, a matching 97.5% CI is presented.

• cP < 0.05 is considered significant for the comparison mainly exercise vs. diet, a matching 95% CI is presented.