Table 2.

Meta-analyses of published data on Caucasians with data from present GWAS

Gene or locusdbSNP IDReferencePublished OR (allelic model)Allelic OR (present GWAS)Meta-analysisPassqPublished OR (additive model)OR of the additive model (present GWAS)Meta-analysisPassq
DNA repair
ATMrs664677Akulevich et al. 2009 (77)1.08 (0.87–1.33)1.09 (0.90–1.32)1.09 (0.94–1.25)0.250.311.06 (0.76–1.47)a1.07 (0.83–1.38)a1.07 (0.87–1.30)a0.530.57
1.20 (0.75–1.91)b1.23 (0.78–1.93)b1.22 (0.88–1.69)b0.240.40
BRCA1rs16942Sturgis et al. 2005 (32)0.73 (0.51–1.05)1.04 (0.86–1.25)0.92 (0.81–1.06)0.240.300.80 (0.49–1.29)a1.40 (0.80–1.34)a0.88 (0.74–1.06)a0.180.29
0.41 (0.15–1.10)b1.08 (0.72–1.61)b0.91 (0.68–1.23)b0.560.63
Xu et al. 2012 (26)0.85 (0.68–1.06)
HUS1rs2708906Neta et al. 2011 (25)1.11 (0.93–1.32)1.55 (1.11–2.18)a1.21 (0.91–1.61)a1.34 (1.08–1.67)a8.8 × 10−30.04
2.40 (1.51–3.82)b1.20 (0.92–1.57)b1.52 (1.16–2.00)b2.5 × 10−30.01
XRCC1rs25487Siraj et al. 2008 (28)0.72 (0.41–1.26)0.87 (0.72–1.05)0.92 (0.85–0.99)0.040.060.76 (0.59–0.99)a0.91 (0.82–1.02)a0.110.22
0.87 (0.58–1.34)b0.85 (0.71–1.02)b0.070.17
Ho et al. 2009 (31)0.70 (0.56–0.89)0.76 (0.55–1.05)a
0.47 (0.27–0.82)b
Sigurdson et al. 2009 (27)1.05 (0.91–1.21)1.18 (0.97–1.44)a
0.95 (0.68–1.32)b
Akulevich et al. 2009 (77)0.86 (0.69–1.07)0.68 (0.50–0.94)a
0.90 (0.56–1.45)b
García-Qu. et al. 2011 (30)1.00 (0.82–1.22)1.12 (0.84–1.50)a
0.91 (0.59–1.40)b
Fard-Esf. et al. 2011 (78)0.87 (0.63–1.20)0.73 (0.47–1.15)a
0.90 (0.44–1.85)b
Santos et al. 2012 (79)0.96 (0.69–1.35)0.90 (0.55–1.47)a
0.98 (0.46–2.10)b
XRCC3rs1799796García-Qu. et al. 2011 (30)0.85 (0.68–1.06)0.86 (0.70–1.06)0.86 (0.73–1.00)0.040.060.92 (0.69–1.21)a0.80 (0.62–1.03)a0.85 (0.71–1.03)a0.460.52
0.60 (0.33–1.11)b0.87 (0.51–1.48)b0.74 (0.50–1.11)b0.370.44
XRCC7rs7830743Siraj et al. 2008 (28)0.99 (0.65–1.49)1.07 (0.78–1.47)1.24 (1.01–1.54)0.040.060.96 (0.60–1.54)a1.07 (0.77–1.50)a1.30 (1.03–1.64)a0.030.09
1.11 (0.27–4.49)b1.12 (0.27–4.72)b1.13 (0.49–2.61)b0.780.81
Rahimi et al. 2012 (33)1.90 (1.29–2.79)2.42 (1.55–3.81)a
1.16 (0.25–5.29)b
ZNF350rs2278420Sigurdson et al. 2009 (27)0.99 (0.84–1.16)0.85 (0.67–1.09)0.95 (0.83–1.08)0.270.311.05 (0.86–1.28)a0.86 (0.65–1.13)a0.98 (0.84–1.15)a0.810.83
0.83 (0.53–1.32)b0.70 (0.29–1.66)b0.80 (0.53–1.20)b0.280.41
Cell-cycle regulation and apoptosis
WDR3rs4658973Baida et al. 2008 (38)0.35 (0.25–0.47)0.83 (0.70–1.00)0.71 (0.61–0.82)5.7 × 10−61.8 × 10−60.40 (0.26–0.62)a0.65 (0.49–0.86)a0.60 (0.48–0.74)a3.7 × 10−67.8 × 10−5
0.07 (0.03–0.18)b0.74 (0.52–1.06)b0.64 (0.47–0.87)b4.5 × 10−31.7 × 10−2
Akdi et al. 2010 (80)1.09 (0.77–1.55)0.81 (0.46–1.41)a
1.29 (0.63–2.64)b
Xenobiotic metabolism
CYP1A1rs4646903Siraj et al. 2008 (40)1.42 (0.88–2.30)1.28 (0.95–1.73)1.16 (0.60–2.24)a1.32 (0.96–1.80)a1.29 (0.97–1.71)a0.120.23
2.42 (0.86–6.83)b1.40 (0.26–7.70)b2.09 (0.86–5.06)b0.290.41
CYP1A1rs1799814Siraj et al. 2008 (40)1.87 (1.44–2.42)1.85 (1.27–2.70)1.86 (1.50–2.30)1.3 × 10−84.4 × 10−81.91 (1.36–2.70)a1.77 (1.20–2.60)a1.85 (1.43–2.39)a2.7 × 10−67.8 × 10−5
3.48 (1.74–6.96)b5.03 (062–41.1)b3.61 (1.87–6.97)b1.3 × 10−41.1 × 10−3
CYP26B1rs12622950Asc.-Kilfoy et al. 2012 (42)1.10 (0.88–1.38)1.32 (0.96–1.83)a1.04 (0.79–1.36)a1.14 (0.93–1.41)a0.200.29
1.69 (0.72–3.95)b1.41 (0.76–2.60)b1.50 (0.91–2.46)b0.110.24
CYP26B1rs7606254Asc.-Kilfoy et al. 2012 (42)1.14 (0.89–1.46)1.07 (0.76–1.53)a1.11 (0.84–1.46)a1.10 (0.88–1.36)a0.410.48
2.07 (0.80–5.34)b1.57 (0.64–3.87)b1.79 (0.93–3.44)b0.680.73
CYP26B1rs707718Asc.-Kilfoy et al. 2012 (42)0.99 (0.79–1.25)0.80 (0.57–1.13)a0.90 (0.69–1.17)a0.86 (0.70–1.06)a0.160.28
2.05 (0.86–4.91)b1.51 (0.68–3.35)b1.74 (0.96–3.31)b0.070.17
MTHFRrs1801133Siraj et al. 2008 (40)1.47 (0.87–2.47)1.11 (0.93–1.33)1.18 (1.00–1.69)0.050.081.77 (0.96–3.29)a1.20 (0.90–1.60)a1.34 (1.05–1.73)a0.020.07
0.95 (0.12–7.54)b1.21 (0.86–1.71)b1.22 (0.87–1.71)b0.260.40
Prasad et al. 2011 (44)2.20 (1.00–4.86)2.21 (0.92–5.30)a
2.65 (0.16–42.9)b
NAT2rs1799929Hernández et al. 2008 (45)0.70 (0.51–0.96)0.97 (0.81–1.16)0.89 (0.76–1.05)0.160.230.64 (0.37–1.10)a0.85 (0.64–1.11)a0.80 (0.63–1.02)a0.070.17
0.51 (0.27–0.96)b0.99 (0.69–1.43)b0.83 (0.60–1.15)b0.260.40
SOD1rs1041740Asc.-Kilfoy et al. 2012 (42)1.42 (1.14–1.76)1.12 (0.93–1.34)1.23 (1.08–1.42)2.7 × 10−35.5 × 10−31.48 (1.09–2.00)a1.20 (0.92–1.57)a1.32 (1.08–1.61)a7.1 × 10−30.04
1.86 (1.15–3.02)b1.17 (0.80–1.71)b1.40 (1.04–1.88)b0.030.09
SOD1rs12626475Asc.-Kilfoy et al. 2012 (42)1.33 (1.08–1.64)1.10 (0.92–1.33)1.20 (1.04–1.38)0.010.021.33 (0.98–1.79)a1.18 (0.91–1.54)a1.24 (1.02–1.52)a0.030.09
1.73 (1.09–2.73)b1.16 (0.80–1.69)b1.36 (1.02–1.82)b0.040.11
UGT2B7rs3924194Asc.-Kilfoy et al. 2012 (42)0.66 (0.49–0.88)0.84 (0.61–1.16)0.74 (0.53–1.05)a0.82 (0.59–1.14)a0.73 (0.57–0.94)a0.010.04
0.31 (0.12–0.85)b0.97 (0.16–5.82)b0.37 (0.15–0.91)b0.030.09
Thyroid function
THRBrs826377Pastor et al. 2012 (48)1.01 (0.79–1.29)1.00 (0.81–1.24)1.06 (0.94–1.21)0.350.381.08 (0.81–1.45)a1.13 (0.87–1.46)a1.11 (0.91–1.34)a0.300.39
0.80 (0.67–1.73)b0.76 (0.44–1.32)b0.77 (0.49–1.21)b0.260.40
TPOrs1042589Cipollini et al. 2013 (49)0.94 (0.84–1.05)0.89 (0.74–1.06)0.93 (0.85–1.02)0.120.170.98 (0.81–1.18)a0.76 (0.56–1.03)a0.92 (0.79–1.06)a0.240.33
0.87 (0.69–1.10)b0.78 (0.54–1.11)b0.86 (0.73–1.03)b0.100.23
Cipollini et al. 2013 (49)0.94 (0.78–1.14)0.88 (0.65–1.19)a
0.90 (0.62–1.32)b
TRHRrs4129682Akdi et al. 2011 (47)0.99 (0.82–1.19)0.88 (0.74–1.05)0.93 (0.82–1.37)0.270.311.15 (0.83–1.58)a1.09 (0.83–1.44)a1.12 (0.90–1.38)a0.310.39
0.96 (0.65–1.41)b0.74 (0.52–1.04)b0.83 (0.64–1.07)b0.150.32
TRHRrs7823804Akdi et al. 2011 (47)0.94 (0.77–1.14)0.94 (0.77–1.14)0.94 (0.82–1.08)0.370.390.91 (0.69–1.22)a1.03 (0.80–1.34)a0.97 (0.80–1.19)a0.800.83
0.89 (0.57–1.41)b0.80 (0.52–1.22)b0.84 (0.62–1.15)b0.270.41
TSHRrs11845164Pastor et al. 2012 (48)1.08 (0.83–1.41)1.21 (0.91–1.61)1.14 (0.94–1.38)0.190.260.96 (0.71–1.31)a1.37 (1.00–1.88)a1.14 (0.92–1.43)a0.240.33
2.22 (0.81–6.07)b0.70 (0.26–1.89)b1.24 (0.61–2.51)b0.550.62
TSHRrs8019570Pastor et al. 2012 (48)1.09 (0.83–1.42)1.21 (0.91–1.61)1.14 (0.94–1.39)0.170.230.99 (0.73–1.35)a1.37 (1.00–1.88)a1.16 (0.93–1.45)a0.190.29
2.04 (0.73–5. 7)b0.70 (0.26–1.89)b1.18 (0.58–2.40)b0.650.72
HRASrs12628Khan et al. 2013 (50)5.82 (3.80–8.93)1.23 (1.02–1.48)2.64 (0.58–12.1)0.210.276.66 (3.66–12.1)a1.51 (1.16–1.96)a3.09 (0.72–13.2)a0.130.24
9.86 (4.08–23.8)b1.31 (0.89–1.92)b3.45 (0.48–24.9)b0.220.40
RETrs1799939Ho et al. 2005 (52)0.79 (0.50–1.25)1.14 (0.92–1.41)1.05 (0.93–1.19)0.430.440.67 (0.38–1.19)a1.29 (0.99–1.67)a1.08 (0.92–1.25)a0.350.43
0.97 (0.32–3.07)b0.93 (0.51–1.67)b1.04 (0.72–1.50)b0.840.86
Sigurdson et al. 2009 (27)1.04 (0.88–1.23)1.02 (0.84–1.25)a
1.15 (0.69–1.93)b
Immune response and inflammation
ALOX12rs1126667Prasad et al. 2012 (53)2.06 (1.45–2.93)0.99 (0.83–1.89)1.74 (1.28–2.37)4.0 × 10−48.9 × 10−43.01 (1.88–4.82)a1.34 (1.02–1.75)a1.63 (1.29–2.06)a4.3 × 10−56.0 × 10−4
2.75 (0.49–15.6)b0.85 (0.59–1.22)b0.89 (0.63–1.27)b0.530.62
SERPINA5rs6115Brenner et al. 2013 (56)1.72 (1.40–2.12)1.02 (0.85–1.24)1.32 (0.79–2.21)0.280.311.76 (1.29–2.41)a1.09 (0.84–1.41)a1.37 (0.86–2.19)a0.190.29
2.52 (1.66–3.83)b0.98 (0.65–1.49)b1.57 (0.62–3.97)b0.340.43
SERPINA5rs6112Brenner et al. 2013 (56)1.61 (1.31–1.99)1.02 (0.85–1.24)1.28 (0.82–2.00)0.280.311.76 (1.30–2.37)a1.09 (0.84–1.41)a1.38 (0.86–2.20)a0.180.29
2.74 (1.63–4.62)b0.98 (0.65–1.49)b1.62 (0.59–4.43)b0.350.43
SERPINA5rs6108Brenner et al. 2013 (56)1.48 (1.20–1.81)1.04 (0.86–1.26)1.24 (0.88–1.75)0.220.281.39 (1.02–1.89)a1.09 (0.84–1.41)a1.21 (0.96–1.54)a0.110.22
2.41 (1.53–3.78)b1.02 (0.67–1.56)b1.56 (0.67–3.63)b0.300.41
TICAM1rs2292151Brenner et al. 2013 (56)1.46 (1.16–1.84)1.09 (0.89–1.34)1.24 (1.06–1.45)7.1 × 10−30.011.43 (1.06–1.93)a0.91 (0.70–1.18)a1.10 (0.91–1.34)a0.320.42
2.15 (1.19–3.88)b1.69 (0.99–2.91)b1.89 (1.27–2.82)b1.8 × 10−30.01
Other cancer genes
ATG16L1rs2241880Huijbers et al. 2012 (57)0.76 (0.60–0.98)0.83 (0.70–0.99)0.81 (0.70–0.93)3.6 × 10−37.6 × 10−30.67 (0.44–1.01)a0.97 (0.73–1.30)a0.86 (0.68–1.08)a0.190.29
0.57 (0.35–0.93)b0.67 (0.47–0.95)b0.63 (0.48–0.84)b1.7 × 10−30.01
FTOrs17817288Kitahara et al. 2012 (62)1.37 (1.12–1.68)1.28 (1.07–1.53)1.32 (1.15–1.51)6.4 × 10−51.6 × 10−41.46 (1.01–2.11)a1.31 (0.99–1.74)a1.36 (1.09–1.71)a6.8 × 10−30.04
1.98 (1.30–3.02)b1.63 (1.15–2.30)b1.76 (1.35–2.30)b3.2 × 10−56.7 × 10−4
FTOrs11642841Kitahara et al. 2012 (62)0.74 (0.60–0.91)0.78 (0.65–0.93)0.76 (0.67–0.87)3.8 × 10−51.2 × 10−40.64 (0.47–0.87)a0.88 (0.67–1.16)a0.76 (0.62–0.94)a9.7 × 10−30.04
0.61 (0.40–0.94)b0.59 (0.42–0.84)b0.60 (0.45–0.79)b3.7 × 10−42.2 × 10−3
FTOrs1121980Kitahara et al. 2012 (62)0.76 (0.62–0.93)0.75 (0.63–0.89)0.75 (0.66–0.86)2.0 × 10−55.7 × 10−50.70 (0.51–0.96)a0.84 (0.63–1.19)a0.76 (0.60–0.96)a0.020.07
0.60 (0.39–0.92)b0.55 (0.39–0.78)b0.57 (0.43–0.75)b7.5 × 10−57.9 × 10−4
FTOrs8050136Kitahara et al. 2012 (62)0.77 (0.62–0.94)0.75 (0.63–0.89)0.76 (0.67–0.86)1.6 × 10−54.8 × 10−50.73 (0.54–1.00)a0.84 (0.63–1.19)a0.78 (0.62–0.98)a0.030.09
0.59 (0.38–0.93)b0.55 (0.39–0.78)b0.56 (0.43–0.74)b2.8 × 10−56.7 × 10−4
FTOrs9939609Kitahara et al. 2012 (62)0.77 (0.62–0.94)0.77 (0.65–0.93)0.77 (0.67–0.88)1.7 × 10−43.9 × 10−40.74 (0.54–1.00)a0.88 (0.67–1.16)a0.81 (0.66–1.00)a0.050.13
0.60 (0.38–0.93)b0.58 (0.41–0.83)b0.59 (0.45–0.78)b2.8 × 10−41.9 × 10−3
FTOrs7202116Kitahara et al. 2012 (62)0.77 (0.63–0.95)0.75 (0.63–0.89)0.76 (0.66–0.87)9.8 × 10−52.5 × 10−40.74 (0.55–1.01)a0.84 (0.63–1.19)a0.78 (0.62–0.99)a0.040.11
0.60 (0.38–0.93)b0.55 (0.39–0.78)b0.57 (0.43–0.75)b7.5 × 10−57.9 × 10−4
HDAC4rs6749348Neta et al. 2011 (25)0.85 (0.62–1.16)0.41 (0.26–0.65)a0.78 (0.56–1.08)a0.58 (0.31–1.08)a0.090.20
0.28 (0.03–2.46)b1.92 (0.39–9.56)b0.97 (0.27–3.54)b0.970.97
HDAC4rs7584828Neta et al. 2011 (25)0.82 (0.64–1.05)0.55 (0.38–0.79)a0.76 (0.58–1.00)a0.68 (0.54–0.84)a4.0 × 10−44.2 × 10−3
0.33 (0.08–1.28)b0.96 (0.41–2.25)b0.71 (0.35–1.46)b0.350.43
IGFBP3rs2132572Xu et al. 2012 (66)c0.60 (0.40–0.80)0.86 (0.66–1.13)0.77 (0.61–0.96)0.02
PIK3CArs17849071Xing et al. 2012 (81)0.71 (0.51–0.99)0.52 (0.23–1.19)a0.67 (0.47–0.96))a0.64 (0.46–0.90)a8.8 × 10−30.04
0.79 (0.21–2.95)b-
SULF1rs6472462Schonfeld et al. 2012 (41)1.28 (1.05–1.56)1.09 (0.91–1.30)1.17 (1.03–1.33)0.020.031.40 (0.97–2.02)a0.92 (0.69–1.23)a1.08 (0.86–1.36)a0.500.55
1.67 (1.11–2.50)b1.19 (0.84–1.68)b1.37 (1.06–1.78)b0.020.07
GWAS or intergenic regions
1p12–13rs4659200Baida et al. 2008 (38)0.84 (0.61–1.15)0.97 (0.81–1.17)0.93 (0.80–1.10)0.410.430.99 (0.62–1.60)a1.15 (0.88–1.50)a1.11 (0.88–1.40)a0.380.46
0.66 (0.35–1.26)b0.85 (0.58–1.24)b0.80 (0.58–1.10)b0.170.34
1p12–13rs7515409Baida et al. 2008 (38)1.02 (0.78–1.34)0.94 (0.79–1.12)0.96 (0.83–1.12)0.610.610.84 (0.54–1.31)a0.80 (0.60–1.07)a0.81 (0.64–1.04)a0.090.20
1.11 (0.62–1.97)b0.89 (0.63–1.26)b0.94 (0.70–1.27)b0.710.75
1p12–13rs1241Baida et al. 2008 (38)0.90 (0.65–1.25)0.92 (0.76–1.10)0.92 (0.78–1.07)0.270.310.69 (0.44–1.10)a1.09 (0.84–1.42)a0.98 (0.77–1.23)a0.830.83
0.74 (0.48–1.16)b0.73 (0.49–1.08)b0.79 (0.55–1.13)b0.200.38
1p31.3rs334725Gudmundsson et al. 2012 (15)1.31 (1.08–1.60)1.39 (0.91–2.13)1.32 (1.10–1.59)2.4 × 10−35.1 × 10−31.33 (0.86–2.05)a
2.74 (0.30–24.6)b
2q35rs966423Gudmundsson et al. 2012 (15)1.34 (1.22–1.47)1.26 (1.06–1.51)1.27 (1.19–1.35)1.0 × 10−131.3 × 10−120.98 (0.74–1.28)a
1.74 (1.21–2.50)b
Liyanarachchi et al. 2013 (82)1.30 (1.12–1.51)
Liyanarachchi et al. 2013 (82)1.14 (1.01–1.29)
5q24rs2910164Jazdzewski et al. 2008 (74)1.14 (0.96–1.34)0.95 (0.78–1.16)1.01 (0.93–1.09)0.890.921.55 (1.25–1.91)a0.94 (0.73–1.22)a1.07 (0.97–1.19)a0.190.29
0.50 (0.28–0.89)b0.91 (0.56–1.47)b0.88 (0.73–1.07)b0.190.36
Jones et al. 2012 (75)1.00 (0.88–1.14)1.01 (0.86–1.19)a
0.98 (0.70–1.38)b
Wei et al. 2013 (83)0.95 (0.82–1.09)0.88 (0.71–1.10)a
0.93 (0.70–1.24)b
8p12rs2439302Gudmundsson et al. 2012 (15)1.36 (1.23–1.50)1.12 (0.94–1.34)1.30 (1.23–1.39)4.0 × 10−171.2 × 10−151.10 (0.83–1.45)a
1.28 (0.90–1.83)b
Liyanarachchi et al. 2013 (82)1.46 (1.26–1.70)
Liyanarachchi et al. 2013 (82)1.23 (1.09–1.38)
8q24rs6983267Akdi et al. 2011 (47)0.98 (0.81–1.18)1.02 (0.86–1.22)1.06 (0.99–1.14)0.090.131.14 (0.83–1.57)a1.15 (0.56–1.54)a1.03 (0.91–1.17)a0.650.70
0.94 (0.65–1.36)b1.03 (0.73–1.46)b1.11 (0.96–1.27)b0.150.32
Jones et al. 2012 (75)1.14 (1.03–1.27)1.01 (0.83–1.23)a
1.27 (1.03–1.57)b
Wang et al. 2013 (84)1.01 (0.88–1.15)0.99 (0.80–1.21)a
1.01 (0.78–1.32)b
9q22rs965513Gudmundsson et al. 2009 (16)1.75 (1.59–1.94)1.78 (1.48–2.14)1.85 (1.76–1.95)<10−20<10−201.80 (1.37–2.35)a
3.08 (2.10–4.53)b
Takahashi et al. 2010 (17)1.65 (1.43–1.91)
Jones et al. 2012 (75)1.96 (1.76–2.18)2.12 (1.77–2.55)a
3.89 (3.10–4.86)b
Tomaz et al. 2012 (85)2.81 (1.87–4.22)
Liyanarachchi et al. 2013 (82)2.09 (1.80–2.42)
Liyanarachchi et al. 2013 (82)1.81 (1.59–2.06)
9q22rs7048394Landa et al. 2009 (76)1.46 (1.19–1.78)1.55 (1.29–1.87)1.51 (1.31–1.73)6.3 × 10−92.3 × 10−81.39 (1.07–1.80)a
2.78 (1.80–4.28)b
9q22rs894673Landa et al. 2009 (76)1.39 (1.17–1.65)1.65 (1.38–1.97)1.51 (1.33–1.71)1.3 × 10−108.3 × 10−101.46 (1.09–1.95)a
2.92 (2.02–4.22)b
9q22rs3758249Landa et al. 2009 (76)1.39 (1.17–1.66)1.65 (1.38–1.97)1.51 (1.34–1.72)1.3 × 10−108.3 × 10−101.46 (1.09–1.95)a
2.92 (2.02–4.22)b
9q22rs907577Landa et al. 2009 (76)1.39 (1.17–1.65)1.65 (1.38–1.97)1.51 (1.34–1.71)1.3 × 10−108.3 × 10−101.46 (1.09–1.95)a
2.92 (2.02–4.22)b
9q22rs3021526Landa et al. 2009 (76)1.32 (1.11–1.58)1.55 (1.29–1.87)1.46 (1.29–1.66)4.0 × 10−91.6 × 10−81.39 (1.07–1.80)a
2.78 (1.80–4.28)b
Tomaz et al. 2012 (85)1.89 (1.27–2.82)
9q22rs10119760Landa et al. 2009 (76)1.47 (1.23–1.75)1.65 (1.38–1.97)1.56 (1.34–1.76)1.6 × 10−109.7 × 10−101.46 (1.09–1.95)a
2.92 (2.02–4.22)b
9q22rs1867277Takahashi et al. 2010 (17)1.48 (1.27–1.71)1.65 (1.38–1.97)1.55 (1.38–1.73)2.9 × 10−144.9 × 10−131.46 (1.09–1.95)a
2.92 (2.02–4.22)b
Jones et al. 2012 (75)1.75 (1.57–1.94)1.99 (1.64–2.41)a
3.08 (2.46–3.84)b
Tomaz et al. 2012 (85)1.76 (1.18–2.62)
9q22rs7849497Tomaz et al. 2012 (85)2.45 (1.60–3.76)1.55 (1.29–1.87)1.67 (1.41–1.98)3.2 × 10−91.4 × 10−81.39 (1.07–1.80)a
2.78 (1.80–4.28)b
9q22rs1867278Tomaz et al. 2012 (85)1.76 (1.18–2.62)1.65 (1.38–1.97)1.67 (1.42–1.96)4.4 × 10−102.2 × 10−91.46 (1.09–1.95)a
2.92 (2.02–4.22)b
9q22rs1867279Tomaz et al. 2012 (85)2.52 (1.64–3.86)1.55 (1.29–1.87)1.90 (1.19–3.04)0.010.021.39 (1.07–1.80)a
2.78 (1.80–4.28)b
9q22rs1867280Tomaz et al. 2012 (85)1.68 (1.13–2.49)1.65 (1.38–1.97)1.65 (1.41–1.95)1.4 × 10−96.5 × 10−91.46 (1.09–1.95)a
2.92 (2.02–4.22)b
9q22rs3021523Tomaz et al. 2012 (85)2.39 (1.56–3.67)1.65 (1.38–1.97)1.74 (1.48–2.05)2.7 × 10−112.8 × 10−101.46 (1.09–1.95)a
2.92 (2.02–4.22)b
14q13rs944289Gudmundsson et al. 2009 (16)1.37 (1.24–1.52)1.25 (1.05–1.49)1.25 (1.17–1.33)0.010.021.13 (0.81–1.58)a
1.48 (1.04–2.09)b
Takahashi et al. 2010 (17)1.13 (0.95–1.36)
Jones et al. 2012 (75)1.33 (1.19–1.49)1.31 (1.02–1.68)a
1.76 (1.37–2.25)b
Liyanarachchi et al. 2013 (82)1.25 (1.08–1.46)
Liyanarachchi et al. 2013 (82)1.22 (1.09–1.38)

NOTE: Meta-analyses were performed when both sources showed a Pass < 0.2 (arbitrary chosen in any inheritance model) or when a meta-analysis of data from the literature alone was statistically significant. Statistically significant results at a nominal level of Pass < 0.05 are highlighted in bold.

aHeterozygotes; brare homozygotes; conly dominant model available.