Table 2.

Meta-analyses of published data on Caucasians with data from present GWAS

Gene or locus	dbSNP ID	Reference	Published OR (allelic model)	Allelic OR (present GWAS)	Meta-analysis	P_ass	q	Published OR (additive model)	OR of the additive model (present GWAS)	Meta-analysis	P_ass	q
DNA repair
ATM	rs664677	Akulevich et al. 2009 (77)	1.08 (0.87–1.33)	1.09 (0.90–1.32)	1.09 (0.94–1.25)	0.25	0.31	1.06 (0.76–1.47)^a	1.07 (0.83–1.38)^a	1.07 (0.87–1.30)^a	0.53	0.57
								1.20 (0.75–1.91)^b	1.23 (0.78–1.93)^b	1.22 (0.88–1.69)^b	0.24	0.40
BRCA1	rs16942	Sturgis et al. 2005 (32)	0.73 (0.51–1.05)	1.04 (0.86–1.25)	0.92 (0.81–1.06)	0.24	0.30	0.80 (0.49–1.29)^a	1.40 (0.80–1.34)^a	0.88 (0.74–1.06)^a	0.18	0.29
								0.41 (0.15–1.10)^b	1.08 (0.72–1.61)^b	0.91 (0.68–1.23)^b	0.56	0.63
		Xu et al. 2012 (26)	0.85 (0.68–1.06)
HUS1	rs2708906	Neta et al. 2011 (25)	—	1.11 (0.93–1.32)	—			1.55 (1.11–2.18)^a	1.21 (0.91–1.61)^a	1.34 (1.08–1.67)^a	8.8 × 10⁻³	0.04
								2.40 (1.51–3.82)^b	1.20 (0.92–1.57)^b	1.52 (1.16–2.00)^b	2.5 × 10⁻³	0.01
XRCC1	rs25487	Siraj et al. 2008 (28)	0.72 (0.41–1.26)	0.87 (0.72–1.05)	0.92 (0.85–0.99)	0.04	0.06	—	0.76 (0.59–0.99)^a	0.91 (0.82–1.02)^a	0.11	0.22
								—	0.87 (0.58–1.34)^b	0.85 (0.71–1.02)^b	0.07	0.17
		Ho et al. 2009 (31)	0.70 (0.56–0.89)					0.76 (0.55–1.05)^a
								0.47 (0.27–0.82)^b
		Sigurdson et al. 2009 (27)	1.05 (0.91–1.21)					1.18 (0.97–1.44)^a
								0.95 (0.68–1.32)^b
		Akulevich et al. 2009 (77)	0.86 (0.69–1.07)					0.68 (0.50–0.94)^a
								0.90 (0.56–1.45)^b
		García-Qu. et al. 2011 (30)	1.00 (0.82–1.22)					1.12 (0.84–1.50)^a
								0.91 (0.59–1.40)^b
		Fard-Esf. et al. 2011 (78)	0.87 (0.63–1.20)					0.73 (0.47–1.15)^a
								0.90 (0.44–1.85)^b
		Santos et al. 2012 (79)	0.96 (0.69–1.35)					0.90 (0.55–1.47)^a
								0.98 (0.46–2.10)^b
XRCC3	rs1799796	García-Qu. et al. 2011 (30)	0.85 (0.68–1.06)	0.86 (0.70–1.06)	0.86 (0.73–1.00)	0.04	0.06	0.92 (0.69–1.21)^a	0.80 (0.62–1.03)^a	0.85 (0.71–1.03)^a	0.46	0.52
								0.60 (0.33–1.11)^b	0.87 (0.51–1.48)^b	0.74 (0.50–1.11)^b	0.37	0.44
XRCC7	rs7830743	Siraj et al. 2008 (28)	0.99 (0.65–1.49)	1.07 (0.78–1.47)	1.24 (1.01–1.54)	0.04	0.06	0.96 (0.60–1.54)^a	1.07 (0.77–1.50)^a	1.30 (1.03–1.64)^a	0.03	0.09
								1.11 (0.27–4.49)^b	1.12 (0.27–4.72)^b	1.13 (0.49–2.61)^b	0.78	0.81
		Rahimi et al. 2012 (33)	1.90 (1.29–2.79)					2.42 (1.55–3.81)^a
								1.16 (0.25–5.29)^b
ZNF350	rs2278420	Sigurdson et al. 2009 (27)	0.99 (0.84–1.16)	0.85 (0.67–1.09)	0.95 (0.83–1.08)	0.27	0.31	1.05 (0.86–1.28)^a	0.86 (0.65–1.13)^a	0.98 (0.84–1.15)^a	0.81	0.83
								0.83 (0.53–1.32)^b	0.70 (0.29–1.66)^b	0.80 (0.53–1.20)^b	0.28	0.41
Cell-cycle regulation and apoptosis
WDR3	rs4658973	Baida et al. 2008 (38)	0.35 (0.25–0.47)	0.83 (0.70–1.00)	0.71 (0.61–0.82)	5.7 × 10⁻⁶	1.8 × 10⁻⁶	0.40 (0.26–0.62)^a	0.65 (0.49–0.86)^a	0.60 (0.48–0.74)^a	3.7 × 10⁻⁶	7.8 × 10⁻⁵
								0.07 (0.03–0.18)^b	0.74 (0.52–1.06)^b	0.64 (0.47–0.87)^b	4.5 × 10⁻³	1.7 × 10⁻²
		Akdi et al. 2010 (80)	1.09 (0.77–1.55)					0.81 (0.46–1.41)^a
								1.29 (0.63–2.64)^b
Xenobiotic metabolism
CYP1A1	rs4646903	Siraj et al. 2008 (40)	1.42 (0.88–2.30)	1.28 (0.95–1.73)	—			1.16 (0.60–2.24)^a	1.32 (0.96–1.80)^a	1.29 (0.97–1.71)^a	0.12	0.23
								2.42 (0.86–6.83)^b	1.40 (0.26–7.70)^b	2.09 (0.86–5.06)^b	0.29	0.41
CYP1A1	rs1799814	Siraj et al. 2008 (40)	1.87 (1.44–2.42)	1.85 (1.27–2.70)	1.86 (1.50–2.30)	1.3 × 10⁻⁸	4.4 × 10⁻⁸	1.91 (1.36–2.70)^a	1.77 (1.20–2.60)^a	1.85 (1.43–2.39)^a	2.7 × 10⁻⁶	7.8 × 10⁻⁵
								3.48 (1.74–6.96)^b	5.03 (062–41.1)^b	3.61 (1.87–6.97)^b	1.3 × 10⁻⁴	1.1 × 10⁻³
CYP26B1	rs12622950	Asc.-Kilfoy et al. 2012 (42)	—	1.10 (0.88–1.38)	—			1.32 (0.96–1.83)^a	1.04 (0.79–1.36)^a	1.14 (0.93–1.41)^a	0.20	0.29
								1.69 (0.72–3.95)^b	1.41 (0.76–2.60)^b	1.50 (0.91–2.46)^b	0.11	0.24
CYP26B1	rs7606254	Asc.-Kilfoy et al. 2012 (42)	—	1.14 (0.89–1.46)	—			1.07 (0.76–1.53)^a	1.11 (0.84–1.46)^a	1.10 (0.88–1.36)^a	0.41	0.48
								2.07 (0.80–5.34)^b	1.57 (0.64–3.87)^b	1.79 (0.93–3.44)^b	0.68	0.73
CYP26B1	rs707718	Asc.-Kilfoy et al. 2012 (42)	—	0.99 (0.79–1.25)	—			0.80 (0.57–1.13)^a	0.90 (0.69–1.17)^a	0.86 (0.70–1.06)^a	0.16	0.28
								2.05 (0.86–4.91)^b	1.51 (0.68–3.35)^b	1.74 (0.96–3.31)^b	0.07	0.17
MTHFR	rs1801133	Siraj et al. 2008 (40)	1.47 (0.87–2.47)	1.11 (0.93–1.33)	1.18 (1.00–1.69)	0.05	0.08	1.77 (0.96–3.29)^a	1.20 (0.90–1.60)^a	1.34 (1.05–1.73)^a	0.02	0.07
								0.95 (0.12–7.54)^b	1.21 (0.86–1.71)^b	1.22 (0.87–1.71)^b	0.26	0.40
		Prasad et al. 2011 (44)	2.20 (1.00–4.86)					2.21 (0.92–5.30)^a
								2.65 (0.16–42.9)^b
NAT2	rs1799929	Hernández et al. 2008 (45)	0.70 (0.51–0.96)	0.97 (0.81–1.16)	0.89 (0.76–1.05)	0.16	0.23	0.64 (0.37–1.10)^a	0.85 (0.64–1.11)^a	0.80 (0.63–1.02)^a	0.07	0.17
								0.51 (0.27–0.96)^b	0.99 (0.69–1.43)^b	0.83 (0.60–1.15)^b	0.26	0.40
SOD1	rs1041740	Asc.-Kilfoy et al. 2012 (42)	1.42 (1.14–1.76)	1.12 (0.93–1.34)	1.23 (1.08–1.42)	2.7 × 10⁻³	5.5 × 10⁻³	1.48 (1.09–2.00)^a	1.20 (0.92–1.57)^a	1.32 (1.08–1.61)^a	7.1 × 10⁻³	0.04
								1.86 (1.15–3.02)^b	1.17 (0.80–1.71)^b	1.40 (1.04–1.88)^b	0.03	0.09
SOD1	rs12626475	Asc.-Kilfoy et al. 2012 (42)	1.33 (1.08–1.64)	1.10 (0.92–1.33)	1.20 (1.04–1.38)	0.01	0.02	1.33 (0.98–1.79)^a	1.18 (0.91–1.54)^a	1.24 (1.02–1.52)^a	0.03	0.09
								1.73 (1.09–2.73)^b	1.16 (0.80–1.69)^b	1.36 (1.02–1.82)^b	0.04	0.11
UGT2B7	rs3924194	Asc.-Kilfoy et al. 2012 (42)	0.66 (0.49–0.88)	0.84 (0.61–1.16)	—			0.74 (0.53–1.05)^a	0.82 (0.59–1.14)^a	0.73 (0.57–0.94)^a	0.01	0.04
								0.31 (0.12–0.85)^b	0.97 (0.16–5.82)^b	0.37 (0.15–0.91)^b	0.03	0.09
Thyroid function
THRB	rs826377	Pastor et al. 2012 (48)	1.01 (0.79–1.29)	1.00 (0.81–1.24)	1.06 (0.94–1.21)	0.35	0.38	1.08 (0.81–1.45)^a	1.13 (0.87–1.46)^a	1.11 (0.91–1.34)^a	0.30	0.39
								0.80 (0.67–1.73)^b	0.76 (0.44–1.32)^b	0.77 (0.49–1.21)^b	0.26	0.40
TPO	rs1042589	Cipollini et al. 2013 (49)	0.94 (0.84–1.05)	0.89 (0.74–1.06)	0.93 (0.85–1.02)	0.12	0.17	0.98 (0.81–1.18)^a	0.76 (0.56–1.03)^a	0.92 (0.79–1.06)^a	0.24	0.33
								0.87 (0.69–1.10)^b	0.78 (0.54–1.11)^b	0.86 (0.73–1.03)^b	0.10	0.23
		Cipollini et al. 2013 (49)	0.94 (0.78–1.14)					0.88 (0.65–1.19)^a
								0.90 (0.62–1.32)^b
TRHR	rs4129682	Akdi et al. 2011 (47)	0.99 (0.82–1.19)	0.88 (0.74–1.05)	0.93 (0.82–1.37)	0.27	0.31	1.15 (0.83–1.58)^a	1.09 (0.83–1.44)^a	1.12 (0.90–1.38)^a	0.31	0.39
								0.96 (0.65–1.41)^b	0.74 (0.52–1.04)^b	0.83 (0.64–1.07)^b	0.15	0.32
TRHR	rs7823804	Akdi et al. 2011 (47)	0.94 (0.77–1.14)	0.94 (0.77–1.14)	0.94 (0.82–1.08)	0.37	0.39	0.91 (0.69–1.22)^a	1.03 (0.80–1.34)^a	0.97 (0.80–1.19)^a	0.80	0.83
								0.89 (0.57–1.41)^b	0.80 (0.52–1.22)^b	0.84 (0.62–1.15)^b	0.27	0.41
TSHR	rs11845164	Pastor et al. 2012 (48)	1.08 (0.83–1.41)	1.21 (0.91–1.61)	1.14 (0.94–1.38)	0.19	0.26	0.96 (0.71–1.31)^a	1.37 (1.00–1.88)^a	1.14 (0.92–1.43)^a	0.24	0.33
								2.22 (0.81–6.07)^b	0.70 (0.26–1.89)^b	1.24 (0.61–2.51)^b	0.55	0.62
TSHR	rs8019570	Pastor et al. 2012 (48)	1.09 (0.83–1.42)	1.21 (0.91–1.61)	1.14 (0.94–1.39)	0.17	0.23	0.99 (0.73–1.35)^a	1.37 (1.00–1.88)^a	1.16 (0.93–1.45)^a	0.19	0.29
								2.04 (0.73–5. 7)^b	0.70 (0.26–1.89)^b	1.18 (0.58–2.40)^b	0.65	0.72
HRAS	rs12628	Khan et al. 2013 (50)	5.82 (3.80–8.93)	1.23 (1.02–1.48)	2.64 (0.58–12.1)	0.21	0.27	6.66 (3.66–12.1)^a	1.51 (1.16–1.96)^a	3.09 (0.72–13.2)^a	0.13	0.24
								9.86 (4.08–23.8)^b	1.31 (0.89–1.92)^b	3.45 (0.48–24.9)^b	0.22	0.40
RET	rs1799939	Ho et al. 2005 (52)	0.79 (0.50–1.25)	1.14 (0.92–1.41)	1.05 (0.93–1.19)	0.43	0.44	0.67 (0.38–1.19)^a	1.29 (0.99–1.67)^a	1.08 (0.92–1.25)^a	0.35	0.43
								0.97 (0.32–3.07)^b	0.93 (0.51–1.67)^b	1.04 (0.72–1.50)^b	0.84	0.86
		Sigurdson et al. 2009 (27)	1.04 (0.88–1.23)					1.02 (0.84–1.25)^a
								1.15 (0.69–1.93)^b
Immune response and inflammation
ALOX12	rs1126667	Prasad et al. 2012 (53)	2.06 (1.45–2.93)	0.99 (0.83–1.89)	1.74 (1.28–2.37)	4.0 × 10⁻⁴	8.9 × 10⁻⁴	3.01 (1.88–4.82)^a	1.34 (1.02–1.75)^a	1.63 (1.29–2.06)^a	4.3 × 10⁻⁵	6.0 × 10⁻⁴
								2.75 (0.49–15.6)^b	0.85 (0.59–1.22)^b	0.89 (0.63–1.27)^b	0.53	0.62
SERPINA5	rs6115	Brenner et al. 2013 (56)	1.72 (1.40–2.12)	1.02 (0.85–1.24)	1.32 (0.79–2.21)	0.28	0.31	1.76 (1.29–2.41)^a	1.09 (0.84–1.41)^a	1.37 (0.86–2.19)^a	0.19	0.29
								2.52 (1.66–3.83)^b	0.98 (0.65–1.49)^b	1.57 (0.62–3.97)^b	0.34	0.43
SERPINA5	rs6112	Brenner et al. 2013 (56)	1.61 (1.31–1.99)	1.02 (0.85–1.24)	1.28 (0.82–2.00)	0.28	0.31	1.76 (1.30–2.37)^a	1.09 (0.84–1.41)^a	1.38 (0.86–2.20)^a	0.18	0.29
								2.74 (1.63–4.62)^b	0.98 (0.65–1.49)^b	1.62 (0.59–4.43)^b	0.35	0.43
SERPINA5	rs6108	Brenner et al. 2013 (56)	1.48 (1.20–1.81)	1.04 (0.86–1.26)	1.24 (0.88–1.75)	0.22	0.28	1.39 (1.02–1.89)^a	1.09 (0.84–1.41)^a	1.21 (0.96–1.54)^a	0.11	0.22
								2.41 (1.53–3.78)^b	1.02 (0.67–1.56)^b	1.56 (0.67–3.63)^b	0.30	0.41
TICAM1	rs2292151	Brenner et al. 2013 (56)	1.46 (1.16–1.84)	1.09 (0.89–1.34)	1.24 (1.06–1.45)	7.1 × 10⁻³	0.01	1.43 (1.06–1.93)^a	0.91 (0.70–1.18)^a	1.10 (0.91–1.34)^a	0.32	0.42
								2.15 (1.19–3.88)^b	1.69 (0.99–2.91)^b	1.89 (1.27–2.82)^b	1.8 × 10⁻³	0.01
Other cancer genes
ATG16L1	rs2241880	Huijbers et al. 2012 (57)	0.76 (0.60–0.98)	0.83 (0.70–0.99)	0.81 (0.70–0.93)	3.6 × 10⁻³	7.6 × 10⁻³	0.67 (0.44–1.01)^a	0.97 (0.73–1.30)^a	0.86 (0.68–1.08)^a	0.19	0.29
								0.57 (0.35–0.93)^b	0.67 (0.47–0.95)^b	0.63 (0.48–0.84)^b	1.7 × 10⁻³	0.01
FTO	rs17817288	Kitahara et al. 2012 (62)	1.37 (1.12–1.68)	1.28 (1.07–1.53)	1.32 (1.15–1.51)	6.4 × 10⁻⁵	1.6 × 10⁻⁴	1.46 (1.01–2.11)^a	1.31 (0.99–1.74)^a	1.36 (1.09–1.71)^a	6.8 × 10⁻³	0.04
								1.98 (1.30–3.02)^b	1.63 (1.15–2.30)^b	1.76 (1.35–2.30)^b	3.2 × 10⁻⁵	6.7 × 10⁻⁴
FTO	rs11642841	Kitahara et al. 2012 (62)	0.74 (0.60–0.91)	0.78 (0.65–0.93)	0.76 (0.67–0.87)	3.8 × 10⁻⁵	1.2 × 10⁻⁴	0.64 (0.47–0.87)^a	0.88 (0.67–1.16)^a	0.76 (0.62–0.94)^a	9.7 × 10⁻³	0.04
								0.61 (0.40–0.94)^b	0.59 (0.42–0.84)^b	0.60 (0.45–0.79)^b	3.7 × 10⁻⁴	2.2 × 10⁻³
FTO	rs1121980	Kitahara et al. 2012 (62)	0.76 (0.62–0.93)	0.75 (0.63–0.89)	0.75 (0.66–0.86)	2.0 × 10⁻⁵	5.7 × 10⁻⁵	0.70 (0.51–0.96)^a	0.84 (0.63–1.19)^a	0.76 (0.60–0.96)^a	0.02	0.07
								0.60 (0.39–0.92)^b	0.55 (0.39–0.78)^b	0.57 (0.43–0.75)^b	7.5 × 10⁻⁵	7.9 × 10⁻⁴
FTO	rs8050136	Kitahara et al. 2012 (62)	0.77 (0.62–0.94)	0.75 (0.63–0.89)	0.76 (0.67–0.86)	1.6 × 10⁻⁵	4.8 × 10⁻⁵	0.73 (0.54–1.00)^a	0.84 (0.63–1.19)^a	0.78 (0.62–0.98)^a	0.03	0.09
								0.59 (0.38–0.93)^b	0.55 (0.39–0.78)^b	0.56 (0.43–0.74)^b	2.8 × 10⁻⁵	6.7 × 10⁻⁴
FTO	rs9939609	Kitahara et al. 2012 (62)	0.77 (0.62–0.94)	0.77 (0.65–0.93)	0.77 (0.67–0.88)	1.7 × 10⁻⁴	3.9 × 10⁻⁴	0.74 (0.54–1.00)^a	0.88 (0.67–1.16)^a	0.81 (0.66–1.00)^a	0.05	0.13
								0.60 (0.38–0.93)^b	0.58 (0.41–0.83)^b	0.59 (0.45–0.78)^b	2.8 × 10⁻⁴	1.9 × 10⁻³
FTO	rs7202116	Kitahara et al. 2012 (62)	0.77 (0.63–0.95)	0.75 (0.63–0.89)	0.76 (0.66–0.87)	9.8 × 10⁻⁵	2.5 × 10⁻⁴	0.74 (0.55–1.01)^a	0.84 (0.63–1.19)^a	0.78 (0.62–0.99)^a	0.04	0.11
								0.60 (0.38–0.93)^b	0.55 (0.39–0.78)^b	0.57 (0.43–0.75)^b	7.5 × 10⁻⁵	7.9 × 10⁻⁴
HDAC4	rs6749348	Neta et al. 2011 (25)	—	0.85 (0.62–1.16)	—			0.41 (0.26–0.65)^a	0.78 (0.56–1.08)^a	0.58 (0.31–1.08)^a	0.09	0.20
								0.28 (0.03–2.46)^b	1.92 (0.39–9.56)^b	0.97 (0.27–3.54)^b	0.97	0.97
HDAC4	rs7584828	Neta et al. 2011 (25)	—	0.82 (0.64–1.05)	—			0.55 (0.38–0.79)^a	0.76 (0.58–1.00)^a	0.68 (0.54–0.84)^a	4.0 × 10⁻⁴	4.2 × 10⁻³
								0.33 (0.08–1.28)^b	0.96 (0.41–2.25)^b	0.71 (0.35–1.46)^b	0.35	0.43
IGFBP3	rs2132572	Xu et al. 2012 (66)^c	0.60 (0.40–0.80)	0.86 (0.66–1.13)	0.77 (0.61–0.96)	0.02
PIK3CA	rs17849071	Xing et al. 2012 (81)	—	0.71 (0.51–0.99)	—			0.52 (0.23–1.19)^a	0.67 (0.47–0.96))^a	0.64 (0.46–0.90)^a	8.8 × 10⁻³	0.04
								—	0.79 (0.21–2.95)^b	-
SULF1	rs6472462	Schonfeld et al. 2012 (41)	1.28 (1.05–1.56)	1.09 (0.91–1.30)	1.17 (1.03–1.33)	0.02	0.03	1.40 (0.97–2.02)^a	0.92 (0.69–1.23)^a	1.08 (0.86–1.36)^a	0.50	0.55
								1.67 (1.11–2.50)^b	1.19 (0.84–1.68)^b	1.37 (1.06–1.78)^b	0.02	0.07
GWAS or intergenic regions
1p12–13	rs4659200	Baida et al. 2008 (38)	0.84 (0.61–1.15)	0.97 (0.81–1.17)	0.93 (0.80–1.10)	0.41	0.43	0.99 (0.62–1.60)^a	1.15 (0.88–1.50)^a	1.11 (0.88–1.40)^a	0.38	0.46
								0.66 (0.35–1.26)^b	0.85 (0.58–1.24)^b	0.80 (0.58–1.10)^b	0.17	0.34
1p12–13	rs7515409	Baida et al. 2008 (38)	1.02 (0.78–1.34)	0.94 (0.79–1.12)	0.96 (0.83–1.12)	0.61	0.61	0.84 (0.54–1.31)^a	0.80 (0.60–1.07)^a	0.81 (0.64–1.04)^a	0.09	0.20
								1.11 (0.62–1.97)^b	0.89 (0.63–1.26)^b	0.94 (0.70–1.27)^b	0.71	0.75
1p12–13	rs1241	Baida et al. 2008 (38)	0.90 (0.65–1.25)	0.92 (0.76–1.10)	0.92 (0.78–1.07)	0.27	0.31	0.69 (0.44–1.10)^a	1.09 (0.84–1.42)^a	0.98 (0.77–1.23)^a	0.83	0.83
								0.74 (0.48–1.16)^b	0.73 (0.49–1.08)^b	0.79 (0.55–1.13)^b	0.20	0.38
1p31.3	rs334725	Gudmundsson et al. 2012 (15)	1.31 (1.08–1.60)	1.39 (0.91–2.13)	1.32 (1.10–1.59)	2.4 × 10⁻³	5.1 × 10⁻³	—	1.33 (0.86–2.05)^a	—
								—	2.74 (0.30–24.6)^b	—
2q35	rs966423	Gudmundsson et al. 2012 (15)	1.34 (1.22–1.47)	1.26 (1.06–1.51)	1.27 (1.19–1.35)	1.0 × 10⁻¹³	1.3 × 10⁻¹²	—	0.98 (0.74–1.28)^a	—
								—	1.74 (1.21–2.50)^b	—
		Liyanarachchi et al. 2013 (82)	1.30 (1.12–1.51)					—
								—
		Liyanarachchi et al. 2013 (82)	1.14 (1.01–1.29)					—
								—
5q24	rs2910164	Jazdzewski et al. 2008 (74)	1.14 (0.96–1.34)	0.95 (0.78–1.16)	1.01 (0.93–1.09)	0.89	0.92	1.55 (1.25–1.91)^a	0.94 (0.73–1.22)^a	1.07 (0.97–1.19)^a	0.19	0.29
								0.50 (0.28–0.89)^b	0.91 (0.56–1.47)^b	0.88 (0.73–1.07)^b	0.19	0.36
		Jones et al. 2012 (75)	1.00 (0.88–1.14)					1.01 (0.86–1.19)^a
								0.98 (0.70–1.38)^b
		Wei et al. 2013 (83)	0.95 (0.82–1.09)					0.88 (0.71–1.10)^a
								0.93 (0.70–1.24)^b
8p12	rs2439302	Gudmundsson et al. 2012 (15)	1.36 (1.23–1.50)	1.12 (0.94–1.34)	1.30 (1.23–1.39)	4.0 × 10⁻¹⁷	1.2 × 10⁻¹⁵	—	1.10 (0.83–1.45)^a	—
								—	1.28 (0.90–1.83)^b	—
		Liyanarachchi et al. 2013 (82)	1.46 (1.26–1.70)					—
								—
		Liyanarachchi et al. 2013 (82)	1.23 (1.09–1.38)					—
								—
8q24	rs6983267	Akdi et al. 2011 (47)	0.98 (0.81–1.18)	1.02 (0.86–1.22)	1.06 (0.99–1.14)	0.09	0.13	1.14 (0.83–1.57)^a	1.15 (0.56–1.54)^a	1.03 (0.91–1.17)^a	0.65	0.70
								0.94 (0.65–1.36)^b	1.03 (0.73–1.46)^b	1.11 (0.96–1.27)^b	0.15	0.32
		Jones et al. 2012 (75)	1.14 (1.03–1.27)					1.01 (0.83–1.23)^a
								1.27 (1.03–1.57)^b
		Wang et al. 2013 (84)	1.01 (0.88–1.15)					0.99 (0.80–1.21)^a
								1.01 (0.78–1.32)^b
9q22	rs965513	Gudmundsson et al. 2009 (16)	1.75 (1.59–1.94)	1.78 (1.48–2.14)	1.85 (1.76–1.95)	<10⁻²⁰	<10⁻²⁰	—	1.80 (1.37–2.35)^a	—
								—	3.08 (2.10–4.53)^b	—
		Takahashi et al. 2010 (17)	1.65 (1.43–1.91)					—
								—
		Jones et al. 2012 (75)	1.96 (1.76–2.18)					2.12 (1.77–2.55)^a
								3.89 (3.10–4.86)^b
		Tomaz et al. 2012 (85)	2.81 (1.87–4.22)					—
								—
		Liyanarachchi et al. 2013 (82)	2.09 (1.80–2.42)					—
								—
		Liyanarachchi et al. 2013 (82)	1.81 (1.59–2.06)					—
								—
9q22	rs7048394	Landa et al. 2009 (76)	1.46 (1.19–1.78)	1.55 (1.29–1.87)	1.51 (1.31–1.73)	6.3 × 10⁻⁹	2.3 × 10⁻⁸	—	1.39 (1.07–1.80)^a	—
								—	2.78 (1.80–4.28)^b	—
9q22	rs894673	Landa et al. 2009 (76)	1.39 (1.17–1.65)	1.65 (1.38–1.97)	1.51 (1.33–1.71)	1.3 × 10⁻¹⁰	8.3 × 10⁻¹⁰	—	1.46 (1.09–1.95)^a	—
								—	2.92 (2.02–4.22)^b	—
9q22	rs3758249	Landa et al. 2009 (76)	1.39 (1.17–1.66)	1.65 (1.38–1.97)	1.51 (1.34–1.72)	1.3 × 10⁻¹⁰	8.3 × 10⁻¹⁰	—	1.46 (1.09–1.95)^a	—
								—	2.92 (2.02–4.22)^b	—
9q22	rs907577	Landa et al. 2009 (76)	1.39 (1.17–1.65)	1.65 (1.38–1.97)	1.51 (1.34–1.71)	1.3 × 10⁻¹⁰	8.3 × 10⁻¹⁰	—	1.46 (1.09–1.95)^a	—
								—	2.92 (2.02–4.22)^b	—
9q22	rs3021526	Landa et al. 2009 (76)	1.32 (1.11–1.58)	1.55 (1.29–1.87)	1.46 (1.29–1.66)	4.0 × 10⁻⁹	1.6 × 10⁻⁸	—	1.39 (1.07–1.80)^a	—
								—	2.78 (1.80–4.28)^b	—
		Tomaz et al. 2012 (85)	1.89 (1.27–2.82)					—
								—
9q22	rs10119760	Landa et al. 2009 (76)	1.47 (1.23–1.75)	1.65 (1.38–1.97)	1.56 (1.34–1.76)	1.6 × 10⁻¹⁰	9.7 × 10⁻¹⁰	—	1.46 (1.09–1.95)^a	—
								—	2.92 (2.02–4.22)^b	—
9q22	rs1867277	Takahashi et al. 2010 (17)	1.48 (1.27–1.71)	1.65 (1.38–1.97)	1.55 (1.38–1.73)	2.9 × 10⁻¹⁴	4.9 × 10⁻¹³	—	1.46 (1.09–1.95)^a	—
								—	2.92 (2.02–4.22)^b	—
		Jones et al. 2012 (75)	1.75 (1.57–1.94)					1.99 (1.64–2.41)^a
								3.08 (2.46–3.84)^b
		Tomaz et al. 2012 (85)	1.76 (1.18–2.62)					—
								—
9q22	rs7849497	Tomaz et al. 2012 (85)	2.45 (1.60–3.76)	1.55 (1.29–1.87)	1.67 (1.41–1.98)	3.2 × 10⁻⁹	1.4 × 10⁻⁸	—	1.39 (1.07–1.80)^a	—
								—	2.78 (1.80–4.28)^b	—
9q22	rs1867278	Tomaz et al. 2012 (85)	1.76 (1.18–2.62)	1.65 (1.38–1.97)	1.67 (1.42–1.96)	4.4 × 10⁻¹⁰	2.2 × 10⁻⁹	—	1.46 (1.09–1.95)^a	—
								—	2.92 (2.02–4.22)^b	—
9q22	rs1867279	Tomaz et al. 2012 (85)	2.52 (1.64–3.86)	1.55 (1.29–1.87)	1.90 (1.19–3.04)	0.01	0.02	—	1.39 (1.07–1.80)^a	—
								—	2.78 (1.80–4.28)^b	—
9q22	rs1867280	Tomaz et al. 2012 (85)	1.68 (1.13–2.49)	1.65 (1.38–1.97)	1.65 (1.41–1.95)	1.4 × 10⁻⁹	6.5 × 10⁻⁹	—	1.46 (1.09–1.95)^a	—
								—	2.92 (2.02–4.22)^b	—
9q22	rs3021523	Tomaz et al. 2012 (85)	2.39 (1.56–3.67)	1.65 (1.38–1.97)	1.74 (1.48–2.05)	2.7 × 10⁻¹¹	2.8 × 10⁻¹⁰	—	1.46 (1.09–1.95)^a	—
								—	2.92 (2.02–4.22)^b	—
14q13	rs944289	Gudmundsson et al. 2009 (16)	1.37 (1.24–1.52)	1.25 (1.05–1.49)	1.25 (1.17–1.33)	0.01	0.02	—	1.13 (0.81–1.58)^a	—
								—	1.48 (1.04–2.09)^b	—
		Takahashi et al. 2010 (17)	1.13 (0.95–1.36)					—
								—
		Jones et al. 2012 (75)	1.33 (1.19–1.49)					1.31 (1.02–1.68)^a
								1.76 (1.37–2.25)^b
		Liyanarachchi et al. 2013 (82)	1.25 (1.08–1.46)				—
							—
		Liyanarachchi et al. 2013 (82)	1.22 (1.09–1.38)				—
							—

NOTE: Meta-analyses were performed when both sources showed a P_ass < 0.2 (arbitrary chosen in any inheritance model) or when a meta-analysis of data from the literature alone was statistically significant. Statistically significant results at a nominal level of P_ass < 0.05 are highlighted in bold.

^aHeterozygotes; ^brare homozygotes; ^conly dominant model available.