Table 4.

Treatment effects on biomarkers adjusted for change in fat percentage or change in VO2peak (mL/min)

TERa (97.5% CI): intervention vs. controlPbTERa (95% CI): mainly exercise vs. dietPc
Adjustment for change in fat percentage
hsCRP (mg/L)
 Diet0.87 (0.57–1.32)0.296
 Mainly exercise0.77 (0.48–1.24)0.0910.89 (0.72–1.09)0.243
IL6 (pg/mL)
 Diet0.94 (0.68–1.32)0.604
 Mainly exercise0.93 (0.64–1.37)0.6010.99 (0.84–1.17)0.919
Adiponectin (ng/mL)
 Diet1.02 (0.95–1.10)0.367
 Mainly exercise1.04 (0.96–1.14)0.1491.02 (0.98–1.06)0.335
Leptin (ng/mL)
 Diet0.83 (0.64–1.07)0.023
 Mainly exercise0.93 (0.69–1.25)0.4691.13 (0.99–1.28)0.061
Adjustment for change in VO2 peak
hsCRP (mg/L)
 Diet0.78 (0.53–1.16)0.057
 Mainly exercise0.71 (0.47–1.08)0.0140.91 (0.73–1.13)0.384
IL-6 (pg/mL)
 Diet0.92 (0.67–1.25)0.385
 Mainly exercise0.87 (0.62–1.20)0.1830.95 (0.80–1.12)0.514
Adiponectin (ng/mL)
 Diet1.02 (0.95–1.09)0.473
 Mainly exercise1.04 (0.96–1.12)0.1031.02 (0.99–1.07)0.230
Leptin (ng/mL)
 Diet0.58 (0.45–0.76)<0.001
 Mainly exercise0.56 (0.42–0.75)<0.0010.96 (0.83–1.11)0.574
  • aTER: Treatment effect ratio (and 97.5% or 95% CI). See footnote of Table 3 for the interpretation.

  • bP < 0.025 is considered significant for the comparison of both intervention groups versus control, a matching 97.5% CI is presented.

  • cP < 0.05 is considered significant for the comparison mainly exercise versus diet, a matching 95% CI is presented.