Table 2.

Multivariate analyses of factors associated with HCC

Adjusted OR (95% CI)P
Model 1
Age (years; vs. 30–39)
 40–492.09 (1.55–2.82)<.001
 50–593.36 (2.51–4.51)<.001
 >607.65 (5.42–10.79)<.001
Gender (vs. female)
 Male1.09 (0.87–1.38)0.46
ALT (U/L; vs. <45)
 >457.64 (5.86–9.95)<.001
HBV DNA level (copies/mL; vs. <300)
 300–9,9991.93 (1.32–2.81)<.001
 10,000–999,9995.53 (3.91–7.80)<.001
 >1 million6.78 (4.68–9.83)<.001
Alcohol drinking (vs. No)
 Yes2.55 (1.94–3.36)<.001
rs1229984 (ADH1B; vs. CC)
 CT/TT0.97 (0.67–1.40)0.86
rs671 (ALDH2; vs. GG)
 GA/AA1.19 (0.96–1.47)0.11
Model 2
rs1229984/rs671 genotypea (vs. CC/GG)
 TC or TT/GG1.44 (0.82–2.55)0.21
 CC/GA or AA2.34 (1.14–4.83)0.02
 TC or TT/GA or AA1.61 (0.91–2.85)0.10
Model 3
rs1229984/rs671 genotypea (vs. wild type or one mutant)
 TC or TT/GA or AA1.10 (0.89–1.36)0.38

Abbreviation: HCC, hepatocellular carcinoma.

  • aAlso adjusted for age, gender, ALT, HBV DNA, and alcohol drinking.