Table 3.

Four SNPs replicated for the association with the risk of SCC

Meta-analysisDiscovery stageReplication stage
SNPGeneaLocationChr.PositionbRefEff (minor)MAFOR (95% CI)POR (95% CI)POR (95% CI)P
rs9689649PARK2Intron6162,021,168AC0.221.38 (1.21–1.58)2.73E−061.45 (1.22–1.73)3.15E−051.28 (1.04–1.57)0.02
rs754626SRCIntron2035,450,754TG0.251.32 (1.18–1.47)1.12E−061.34 (1.17–1.53)1.44E−051.26 (1.03–1.55)0.02
rs9643297ST3GAL1Intron8134,552,877AG0.311.32 (1.17–1.50)8.20E−061.42 (1.21–1.68)3.26E−051.21 (1.01–1.45)0.04
rs17247181ERBB2IPIntron565,291,428CT0.101.40 (1.21–1.62)4.22E−061.42 (1.21–1.68)3.08E−051.34 (1.003–1.79)0.048
  • aClosest gene to the genetic variant.

  • bBased on HapMap build 35.