Table 2.

Association between the SNP rs8063761 in the intron region of DEF8 gene and the risk of SCC

Genotype (cases/controls)
DatasetAAATTTOR (95% CI)PPheterogeneity
Discovery seta
 Harvard GWAS178/2,427192/2,16754/4901.26 (1.09–1.47)2.23E−03
 RS-I96/2,710125/2,40537/5191.42 (1.18–1.71)1.66E−04
 RS-II26/18929/9088/9891.25 (0.86–1.71)0.24
 All (meta-analysis)300/5,326346/5,48099/1,9981.32 (1.18–1.47)1.01E−060.60
Replication setb
 Skin cancer study211/267229/22279/501.38 (1.16–1.65)4.09E−04
Combined set (meta-analysis)1.34 (1.22–1.47)1.74E−090.66
  • aAdjusted for age, gender, and the first three principal components in each study.

  • bAdjusted for age and gender.