Table 4.

Combination mediation analyses for ADH1B, ALDH2, alcohol consumption, and HCC risk

Direct effectIndirect effect
ADH1B/ALDH2 genotypeOR (95% CI)aPOR (95% CI)aP
CC/GG1.01.0
CT or TT/GG1.34 (0.64–2.66)0.411.03 (0.93–1.17)0.57
CC/GA or AA1.76 (0.69–5.77)0.311.02 (0.87–1.24)0.79
CT or TT/GA or AA1.67 (0.74–2.54)0.200.73 (0.58–0.88)0.005
  • aAdjusted for age, gender, HBV DNA, and ALT.