Table 3.

Meta-analyses between the non-Caucasian population(s) from the literature and present GWAS

Gene or locusdbSNP IDReferencePublished OR (allelic model)Allelic OR (present GWAS)Meta-analysisPassqPublished OR (additive model)OR of the additive model (present GWAS)Meta-analysisPassq
Cell-cycle regulation and apoptosis
MDM2rs2279744Zhang et al. 2013 (36)c1.50 (1.10–2.00)1.27 (0.91–1.77)1.40 (1.12–1.74)2.6 × 103
Xenobiotic metabolism
GPX3rs3792796Lin et al. 2009 (86)1.15 (0.90–1.46)1.08 (0.90–1.29)1.10 (0.96–1.27)0.170.241.25 (0.90–1.74)a1.02 (0.78–1.33)a1.10 (0.90–1.36)a0.350.45
1.19 (0.66–2.16)b1.19 (0.83–1.72)b1.19 (0.87–1.63)b0.280.40
Immune response and inflammation
IL11RArs1061758Eun et al. 2012 (55)1.62 (1.14–2.28)1.29 (1.02–1.65)1.39 (1.14–1.70)1.0 × 10−30.013.03 (1.52–6.06)a1.24 (0.94–1.64)a1.41 (1.08–1.82)a0.010.09
3.16 (1.42–7.04)b1.87 (0.89–3.93)b2.38 (1.38–4.11)b1.8 × 10−30.02
TLR6rs3775073Kim et al. 2013 (87)1.28 (0.91–1.81)1.14 (0.94–1.38)1.17 (0.99–1.38)0.060.171.21 (0.74–1.99)a1.12 (0.86–1.44)a1.14 (0.91–1.42)a0.260.41
1.67 (0.80–3.47)b1.34 (0.87–2.06)b1.42 (0.98–2.05)b0.060.20
Other cancer genes
FOSBrs12373539Han et al. 2012 (88)0.79 (0.55–1.14)0.84 (0.63–1.12)0.82 (0.65–1.03)0.090.200.74 (0.45–1.22)a0.84 (0.63–1.11)a0.82 (0.64–1.04)a0.100.18
0.66 (0.27–1.62)b0.87 (0.39–1.91)b0.77 (0.43–1.39)b0.390.46
HER2rs1801200Rebaї et al. 2009 (64)1.88 (1.18–3.01)1.00 (0.79–1.28)1.15 (0.92–1.43)0.220.241.36 (0.78–2.37)a0.96 (0.73–1.26)a1.03 (0.80–1.31)a0.830.83
1.32 (0.53–3.31)b
IGF1Rrs2229765Cho et al. 2012 (65)0.56 (0.39–0.80)0.94 (0.79–1.13)0.84 (0.72–0.99)0.040.150.56 (0.35–0.90)a0.86 (0.66–1.13)a0.77 (0.61–0.98)a0.030.09
0.28 (0.11–0.76)b0.94 (0.64–1.38)b0.80 (0.56–1.15)b0.230.40
ITGA6rs11895564Kim et al. 2011 (67)2.04 (1.24–3.37)1.15 (0.95–1.39)1.46 (0.84–2.54)0.180.241.96 (1.12–3.43)a1.01 (0.78–1.31)a1.34 (0.71–2.55)a0.370.45
7.03 (0.64–78.5)b1.44 (0.96–2.18)b2.00 (0.57–7.05)b0.280.40
ITGB1rs2230396Eun et al. 2013 (68)0.90 (0.63–1.28)0.85 (0.65–1.12)0.87 (0.70–1.08)0.200.240.67 (0.39–1.15)a0.78 (0.58–1.06)a0.75 (0.58–0.98)a0.040.09
0.97 (0.46–2.06)b1.16 (0.43–3.17)b1.03 (0.57–1.89)b0.910.91
OPNrs17524488Mu et al. 2013 (70)0.86 (0.71–1.05)0.95 (0.78–1.14)0.91 (0.76–1.04)0.160.240.82 (0.59–1.15)a0.81 (0.63–1.04)a0.81 (0.67–0.99)a0.040.09
0.74 (0.48–1.11)b1.08 (0.70–1.66)b0.88 (0.66–1.19)b0.410.46
OPNrs11730582Mu et al. 2013 (70)2.14 (1.74–2.62)1.04 (0.87–1.24)1.49 (0.73–3.02)0.270.272.05 (1.46–2.90)a0.80 (0.59–1.08)a1.28 (0.51–3.21)a0.610.67
4.31 (2.85–6.52)b1.08 (0.76–1.54)b2.15 (0.55–8.34)b0.270.40
VEGFArs699947Hsiao et al. 2007 (72)1.66 (1.11–2.50)1.19 (0.99–1.42)1.22 (1.05–1.41)8.6 × 10−30.051.89 (1.08–3.32)a1.23 (0.94–1.63)a1.26 (1.01–1.57)a0.040.09
2.30 (0.87–6.13)b1.38 (0.97–1.96)b1.42 (1.04–1.94)b0.030.15

aHeterozygotes; brare homozygotes; conly recessive model available. Statistically significant results at a nominal level of Pass < 0.05 are highlighted in bold.