Table 3.

Mediation analyses for ADH1B, ALDH2, alcohol consumption, and HCC risk

ADH1BALDH2
Effect typeOR (95% CI)a,bPOR (95% CI)b,cP
Marginal0.93 (0.64–1.35)0.701.02 (0.84–1.25)0.83
Without SNP by alcohol interaction
 Direct0.97 (0.67–1.50)0.891.19 (0.97–1.52)0.10
 Indirect0.87 (0.79–0.96).0060.74 (0.67–0.82)<.001
 Proportion of mediation (%)81.3d
With SNP by alcohol interaction
 Direct0.98 (0.58–1.67)0.951.38 (0.98–1.95)0.07
 Indirect0.87 (0.79–0.96).0060.70 (0.61–0.82)<.001
 Proportion of mediation (%)87.6d

Abbreviation: HCC, hepatocellular carcinoma.

  • aCT/TT vs. CC.

  • bAdjusted for age, gender, HBV DNA, ALT, and the other SNPs.

  • cGA/AA vs. GG.

  • dNot valid as effects are in opposite directions.