Table 4.

Association between coffee and cancer in all MECC subjects and in major ethnic subgroups from multivariable logistic regression

CRC (unadjusted)CRC (adjusteda)bColon (adjusteda)Rectum (adjusteda)
Servings/dayNcaseNcontrolOR95% LCL95% UCLPOR95% LCL95% UCLPOR95% LCL95% UCLPOR95% LCL95% UCLP
Total MECC
 <11,3957511.001.001.001.00
 ≥1 and <21,6511,2350.720.640.81<0.0010.780.680.90<0.0010.790.680.920.0020.780.630.970.02
 ≥2 and ≤2.51,2741,2210.560.500.63<0.0010.590.510.68<0.0010.570.490.66<0.0010.540.430.68<0.001
 >2.58258900.500.440.57<0.0010.460.390.54<0.0010.390.330.47<0.0010.500.400.64<0.001
Ashkenazi
 <19875061.001.001.001.00
 ≥1 and <21,1587850.750.660.87<0.0010.820.690.970.020.840.701.000.060.750.570.970.03
 ≥2 and ≤2.57897450.540.470.63<0.0010.590.500.71<0.0010.610.500.74<0.0010.510.380.68<0.001
 >2.53143800.420.350.51<0.0010.440.350.56<0.0010.440.340.56<0.0010.450.320.65<0.001
Sephardi
 <12301351.001.001.001.00
 ≥1 and <23272950.650.500.850.0010.670.490.920.010.620.440.870.0051.010.601.710.96
 ≥2 and ≤2.52843050.550.420.71<0.0010.560.410.77<0.0010.510.360.72<0.0010.810.481.380.45
 >2.51652410.400.300.54<0.0010.370.260.53<0.0010.350.240.51<0.0010.520.290.920.03
Arab
 <1116601.001.001.001.00
 ≥1 and <2121730.860.561.310.480.980.601.590.921.040.611.780.870.800.401.610.54
 ≥2 and ≤2.51861180.820.551.200.300.960.611.490.840.990.611.610.980.890.481.630.70
 >2.53412360.750.531.060.110.870.581.320.520.820.521.280.380.950.551.630.86

Abbreviations: LCL, lower confidence limit; UCL, upper confidence limit.

  • aAdjusted for sex, age, ethnicity, vegetable consumption, sports participation, statin use, daily low-dose aspirin use, smoking status, and family history in a first-degree relative.

  • bAdjusted CRC Ptrend < 0.001 in all MECC participants, Ashkenazi Jews, and Sephardi Jews. Adjusted CRC Ptrend = 0.45 in Arabs.