Table 2.

Effects of exercise interventions on IGF1 and IGF2

Within group analysisBetween groups analysis
Author, yearBaseline [1] [Mean (SD)]1st endpoint [2] [Mean (SD)]2nd endpoint [3] [Mean (SD)]Mean change [Mean (SD)]Δ percentageP valueP value
IGF1 (ng.mL−1)
1Fairey et al.,I: 67.4 (29.1)62.5 (23.9)NA−4.9 (10.7)−7.3%NAP = 0.045
2003 (29)C: 70.0 (21.5)72.6 (24.8)NA2.5 (14.8)3.6%NA
2Schmitz et al.,I: 172.9 (11.6)181.2 (11.6)NA8.3 (6.3)4.8%NAP = 0.16
2005 (35)aC: 194.3 (11.4)190.3 (11.4)NA−4.0 (6.1)−2.0%NA
3Irwin et al.,I: 213.3 (12.6)207.1 (11.2)NA−7.4 (6.0)−2.9%NAP = 0.026
2009 (31)bC: 232.3 (18.7)243.7 (18.5)NA12.7 (6.4)4.8%NA
4Galvao et al.,I: 158.9 (19.4)161.4 (16.1)156.3 (14.3)NA(1–2) 1.6%P > 0.05NA
2008 (30)b(1–3) −1.6%
(2–3) −3.2%
5Janelsins et al.,I: 156.8 (19.6)129.5 (43.8)NA−27.3 (45.1)−17.4%NAP > 0.05
2011 (32)C: 111.8 (82.6)95.1 (58.7)NA−16.6 (66.5)−14.9%NA
6Lee et al., 2013 (33)I: 135.4 (60.2)159.5 (62.1)NANA17.8%P = 0.007NA
7Santa MinaI (A): 159.6 (55.2)169.7 (67.5)161.9 (45.9)NA(1–2) 6.3%NA(1–2) P = 0.129
et al., 2013 (34)(1–3) 1.4%(1–3) P = 0.199
(2–3) −4.6%
I (R): 159.1 (51.2)138.3 (42.6)146.4 (49.5)NA(1–2) −13.1%(1–2) P ≤ 0.05NA
(1–3) −8.0%
(2–3) 5.9%
IGF2 (ng.mL−1)
1Fairey et al.,I: 824.9 (155.5)805.0 (139.9)NA−19.9 (97.1)−2.4%NAP = 0.101
2003 (29)C: 714.5 (148.9)735.3 (152.4)NA20.9 (80.5)2.9%NA
2Schmitz et al.,I: 898.0 (34.9)871.8 (34.9)NA−26.2 (16.7)−3.0%NAP = 0.02
2005 (35)aC: 891.3 (34.4)919.5 (34.4)NA28.3 (16.3)3.2%NA

Abbreviations: A, aerobic exercise group; C, control group; I, intervention group; NA, not applicable; R, resistance training group.

  • aOnly RCT component of the study by Schmitz et al. (35) is included in the analysis.

  • bData presented as mean (SE).