Table 2.

Participant reproductive characteristics by periodontal disease, WHI OS

Periodontal disease
TotalYesNo
(n=73,737)(n=19,262)(n=54,475)Pa
Mean ± SDMean ± SDMean ± SD
Age at menopause48.3 ± 6.248.4 ± 6.148.3 ± 6.20.01
N (%)N (%)N (%)
Age at menarche
 9–1116,145 (21.9)4,529 (23.5)11,616 (21.3)<0.001
 12–1341,119 (55.8)10,694 (55.5)30,425 (55.9)
 ≥1416,473 (22.3)4,039 (21.0)12,434 (22.8)
Age at first birth
 Never pregnant or never had term9,196 (12.6)2,664 (13.9)6,532 (12.1)<0.001
 <207,983 (10.9)2,009 (10.5)5,974 (11.0)
 20–2950,519 (69.0)12,918 (67.5)37,601 (69.5)
 ≥305,547 (7.6)1,539 (8.0)4,008 (7.4)
Parity
 Never pregnant or never had term9,196 (12.6)2,664 (13.9)6,532 (12.1)<0.001
 1–226,011 (35.5)7,090 (37.1)18,921 (35.0)
 3–428,544 (39.0)7,237 (37.8)21,307 (39.4)
 ≥59,494 (13.0)2,139 (11.2)7,355 (13.6)
Family history of breast cancer
 Yes13,173 (18.8)3,427 (18.8)9,746 (18.9)0.84
 No56,717 (81.2)14,803 (81.2)41,914 (81.1)
Mammograms in last 5 years
 1–322,544 (32.9)5,777 (32.0)16,767 (33.2)0.005
 >346,065 (67.1)12,265 (68.0)33,800 (66.8)
Hormone use at year 5
 Never used hormones20,318 (28.4)5,228 (27.9)15,090 (28.6)<0.001
 Former E-alone user7,270 (10.2)1,684 (9.0)5,586 (10.6)
 Current E-alone user15,508 (21.7)3,893 (20.8)11,615 (22.0)
 Former E+P user12,935 (18.1)3,521 (18.8)9,414 (17.8)
 Current E+P user15,526 (21.7)4,394 (23.5)11,132 (21.1)

NOTE: Number of missing data for age at first birth and parity, n = 492; family history of breast cancer, n = 3,847; mammogram in last 5 years, n = 5,128; hormone use at year 5, n = 2,180.

  • aP value for Student t test for continuous variables and for χ2 test for categorical variables.