Table 3.

ORs (95% CI) for colon and rectal cancer according to quartiles of circulating glycer-AGEs by alcohol intake status

Glycer-AGEsa
Sex-specific categories of dietary alcohol intake level (g/day)Q1ORQ2OR (95% CI)Q3OR (95% CI)Q4OR (95% CI)Ptrend
Colon
 Low alcohol status (≤ median)b
  Number of cases/controls135/130145/137119/119104/124
  Matching factorsc 1.000.97 (0.69–1.37)0.79 (0.54–1.15)0.71 (0.46–1.10)0.08
  Multivariate adjustedd 1.001.01 (0.69–1.47)0.79 (0.52–1.20)0.82 (0.51–1.33)0.29
 High alcohol status (> median)b
  Number of cases/controls39/3639/2838/4540/40
  Matching factorsc 1.001.48 (0.68–3.20)0.92 (0.40–2.07)1.11 (0.47–2.58)0.95
  Multivariate adjustedd 1.001.10 (0.46–2.61)0.78 (0.31–1.95)1.17 (0.46–3.03)0.95
Rectum
 Low alcohol status (≤ median)b
  Number of cases/controls51/6470/5738/4657/63
  Matching factorsc 1.001.56 (0.92–2.65)0.95 (0.52–1.73)1.14 (0.66–1.97)0.95
  Multivariate adjustedd 1.001.48 (0.85–2.58)0.95 (0.51–1.78)1.14 (0.64–2.03)0.99
 High alcohol status (> median)b
  Number of cases/controls26/3545/4340/5268/36
  Matching factorsc 1.001.39 (0.69–2.77)1.14 (0.57–2.29)2.85 (1.41–5.79)< 0.01
  Multivariate adjustedd 1.001.41 (0.69–2.88)1.07 (0.52–2.19)2.70 (1.29–5.62)0.01

Abbreviation: Q, quartile.

  • aQuartile cut-offs are same as in Table 2.

  • bAlcohol consumption level was dichotomized based on the sex-specific median values of lifetime alcohol consumption among controls.

  • cModel adjusted for matching factors (age, gender, administrative center, time of the day at blood collection, fasting status, and menopausal status among women) only.

  • dModel adjusted for matching factors plus smoking status/duration/intensity, BMI, total physical activity, education level, diabetes status, total dietary energy consumption, red and processed meat, fiber, and fruits and vegetables.