Table 2.

Circulating glycer-AGEs concentration and the risk of cancers of the colorectum, colon, and rectum

Glycer-AGEs
Type of cancerQ1 (reference) ORQ2OR (95% CI)Q3OR (95% CI)Q4OR (95% CI)Ptrend
Colorectum
 Cut-point [U/mL]a ≤5.42>5.42 and ≤7.03>7.03 and ≤8.65>8.65
 Mean (SD), median [U/mL]4.3 (0.9), 4.46.3 (0.5), 6.37.8 (0.4), 7.710.5 (1.7), 10.0
 Number of cases/controls249/264301/264237/263266/263
 Matching factorsb 1.001.19 (0.94–1.50)0.95 (0.74–1.23)1.07 (0.81–1.42)0.95
 Multivariate adjustedc 1.001.18 (0.92–1.51)0.94 (0.72–1.24)1.10 (0.82–1.49)0.87
Colon
 Cut-point [U/mL]a ≤5.48>5.48 and ≤6.99>6.99 and ≤8.68>8.68
 Mean (SD), median [U/mL]4.3 (0.9), 4.56.3 (0.5), 6.27.7 (0.5), 7.710.5 (1.7), 10.0
 Number of cases/controls174/166184/165157/164144/164
 Matching factorsb 1.001.03 (0.77–1.37)0.88 (0.64–1.20)0.78 (0.55–1.11)0.12
 Multivariate adjustedc 1.001.04 (0.76–1.42)0.86 (0.61–1.22)0.83 (0.57–1.22)0.25
Rectum
 Cut-point [U/mL]a ≤5.36>5.36 and ≤7.12>7.12 and ≤8.61>8.61
 Mean (SD), median [U/mL]4.2 (1.0), 4.46.3 (0.5), 6.47.8 (0.4), 7.710.3 (1.7), 9.5
 Number of cases/controls77/99115/10079/98125/99
 Matching factorsb 1.001.49 (0.99–2.23)1.14 (0.73–1.80)1.90 (1.17–3.10)0.03
 Multivariate adjustedc 1.001.47 (0.96–2.27)1.11 (0.68–1.80)1.90 (1.14–3.19)0.04

Abbreviation: Q, quartile.

  • aBased on control participants only.

  • bModel based on matching factors (age, gender, administrative center, time of the day at blood collection, fasting status, and menopausal status among women) only.

  • cModel based on matching factors plus adjustments for smoking status/duration/intensity, BMI, total physical activity, education level, diabetes status, total dietary energy consumption, and intakes of alcohol, red and processed meat, fiber, and fruits and vegetables.