Table 4.

Cox proportional hazard model for overall survival of local/regional stage patients

Whole groupSubgroup with carcinoid syndromeSubgroup without carcinoid syndrome
HR95% HR confidence limitsPHR95% HR confidence limitsPHR95% HR confidence limitsP
Treatment
 Without octreotide LAR111
 With octreotide LAR1.2530.9281.6920.14151.2440.8361.8520.28141.2630.7392.1560.3929
Carcinoid syndrome
 No1
 Yes0.9730.8611.1000.6660
Age, y
 65–69111
 70–741.2391.0861.4130.00141.0260.7131.4760.89031.2821.1121.4780.0006
 75–791.7591.5462.000<0.00011.6911.1982.3870.00281.7581.5292.021<0.0001
 ≥802.9372.6023.315<0.00012.7311.9673.793<0.00012.9632.5983.379<0.0001
Gender
 Male111
 Female0.7320.6740.795<0.00010.8030.6321.0190.07140.7110.6510.777<0.0001
Race/ethnicity
 Non-Hispanic white111
 Non-Hispanic black1.0650.9281.2220.36791.6681.1582.4040.00600.9940.8571.1540.9412
 Hispanic or Others0.7440.6330.8760.00041.0840.6531.7990.75490.7050.5930.838<0.0001
Region
 Northeast111
 Midwest1.0400.9041.1960.58641.0010.6941.4440.99561.0380.8911.2090.6292
 South1.2101.0571.3840.00561.5011.0282.1900.03531.1671.0091.3490.0370
 West1.1260.9971.2720.05671.2740.9011.8010.17001.1070.9711.2630.1289
Urban/rural status
 Metropolitan111
 Nonmetropolitan0.9680.8391.1180.66021.2050.8021.8110.36890.9360.8021.0920.3987
Census tract median income in quartile
 First quartile1.0200.8251.2620.85431.0160.5561.8560.95920.9900.7861.2460.9319
 Second quartile1.0690.8981.2720.45501.2590.7872.0140.33701.0220.8451.2360.8229
 Third quartile1.0470.9081.2060.52961.2370.8361.8300.28650.9930.8511.1590.9311
 Fourth quartile111
Census tract % below poverty level in quartile
 First quartile111
 Second quartile1.0120.8881.1520.86051.1220.7841.6060.52761.0090.8771.1610.8996
 Third quartile0.9460.8091.1070.48970.9970.6531.5210.98840.9360.7891.110.4457
 Fourth quartile0.9080.7451.1080.34340.7820.4521.3500.37720.9380.7561.1640.5628
Census tract % college in quartile
 First quartile1.3391.1391.5750.00041.1200.6941.8080.64281.4081.1841.6750.0001
 Second quartile1.2381.0711.4300.00391.1660.7861.7280.44561.2871.11.5060.0016
 Third quartile1.0760.9451.2240.26980.8950.6241.2820.54391.1240.9781.2920.1001
 Fourth quartile111
Comorbidity score
 0111
 11.4321.2881.591<0.00011.3500.9991.8260.05111.4601.3031.636<0.0001
 ≥22.3992.1632.662<0.00012.1731.5982.953<0.00012.4482.1902.738<0.0001
 Unknown0.9140.7551.1050.35221.2940.8132.0590.27720.8450.6841.0440.1180
Tumor size
 <1 cm111
 1–2 cm0.9670.8511.0980.60160.9420.6301.4080.77000.9770.8541.1180.7404
 >2 cm1.1020.9721.2490.12951.1190.7491.6730.58181.1020.9651.2590.1503
 Unknown1.0690.9471.2050.27991.4220.9532.1210.08441.0440.9201.1860.5036
Histology grade
 Grade 1111
 Grade 21.2631.0931.4590.00151.1350.7361.7510.56671.2811.0971.4940.0017
 Unspecified (either grade 1 or 2)1.5581.2621.923<0.00012.5321.5034.2680.00051.4211.1241.7960.0033
Primary site
 Larynx, bronchus, lung, trachea, and other respiratory organs111
 Cecum and appendix1.1200.9131.3750.27530.9190.5231.6140.76851.1180.8921.4010.3318
 Colon0.8290.7150.9620.01350.8550.5121.4280.54930.8200.7020.9600.0132
 Small intestine1.3491.2051.511<0.00010.9670.6491.4400.86821.4101.2521.588<0.0001
 Pancreas1.2310.9741.5540.08140.6870.3721.2700.23091.3621.0551.7570.0176
 Others1.2321.0721.4150.00331.1890.7521.8800.45911.2101.0421.4040.0122
Resection of primary tumor
 No111
 Yes0.6300.5670.700<0.00010.6280.4580.8600.00370.6410.5730.718<0.0001
Resection of liver metastases
 No111
 Yes1.1610.5482.4580.69730.6860.1642.8710.60551.3880.5693.3870.4709
Chemotherapy
 No111
 Yes1.5971.3761.854<0.00011.5971.1092.2990.01181.5601.3201.844<0.0001
Radiotherapy
 No111
 Yes1.8451.5512.195<0.00012.0111.2353.2730.00501.8231.5102.202<0.0001
Year of diagnosis
 1999–2003111
 2004–20070.9710.8901.0590.50211.0080.7851.2930.95310.9710.8841.0660.5357