Table 2.

All-cause and colorectal cancer–specific mortality for persons with colorectal cancer by prediagnosis BMI and weight change: the C-CFR, 1997 to 2012

Men and women combinedWomenMen
Deaths/person yearsMultivariable HR (95% CI)aPtrendbPinteraction with sexcDeaths/person yearsMultivariable HR (95% CI)aPtrendbDeaths/person yearsMultivariable HR (95% CI)aPtrendb
All-cause mortality
 BMI recent
  <18.539/4291.62 (1.15–2.28)31/3511.76 (1.18–2.61)
  18.5–<25629/11,4201.00 (ref)360/7,1041.00 (ref)269/4,3161.00 (ref)
  25–<30787/12,8421.12 (1.00–1.25)257/4,8041.10 (0.93–1.30)530/8,0371.11 (0.95–1.29)
  ≥30598/8,5221.29 (1.14–1.45)0.36259/3,8281.33 (1.12–1.58)339/4,6951.23 (1.04–1.46)
  30–<35364/5,6541.19 (1.04–1.37)130/2,1701.25 (1.01–1.54)234/3,4841.16 (0.96–1.39)
  35–<40141/1,7901.43 (1.18–1.73)68/1,0031.31 (1.00–1.73)73/7861.59 (1.21–2.09)
  ≥4093/1,0791.52 (1.21–1.90)0.3961/6541.63 (1.21–2.19)32/4251.19 (0.81–1.74)
  Per 5 kg/m2d1.10 (1.06–1.15)<0.00010.411.11 (1.05–1.17)0.00021.09 (1.03–1.16)0.004
 BMI at age 20 y
  <18.5130/2,2131.06 (0.88–1.28)93/1,6551.04 (0.83–1.31)37/5581.16 (0.82–1.63)
  18.5–<251,342/23,5561.00 (ref)645/12,3011.00 (ref)697/11,2551.00 (ref)
  25–<30400/5,5661.22 (1.08–1.37)90/1,3491.24 (0.98–1.56)310/4,2161.20 (1.04–1.38)
  ≥30116/1,2281.57 (1.28–1.91)0.0847/4172.02 (1.47–2.78)69/8111.32 (1.01–1.71)
  30–<3590/9561.67 (1.34–2.09)34/3032.07 (1.44–2.98)56/6521.48 (1.11–1.98)
  ≥3526/2721.27 (0.85–1.91)0.0913/1131.89 (1.03–3.47)13/1590.86 (0.48–1.55)
  Per 5 kg/m2d1.10 (1.04–1.16)0.00070.0021.23 (1.12–1.35)<0.00011.03 (0.96–1.11)0.4
 Adult weight changee
  Lost weight139/2,0310.97 (0.79–1.20)75/1,0481.19 (0.89–1.60)64/9830.80 (0.59–1.09)
  0–<6 kg393/6,5931.00 (ref)169/3,2211.00 (ref)224/3,3721.00 (ref)
  6–<10 kg327/5,4641.00 (0.86–1.16)151/2,6451.09 (0.86–1.37)176/2,8200.94 (0.76–1.16)
  10–<20 kg561/9,6970.99 (0.87–1.13)222/4,7660.86 (0.69–1.06)339/4,9311.11 (0.93–1.32)
  ≥20 kg584/9,0901.11 (0.97–1.27)0.004267/4,2541.15 (0.93–1.41)317/4,8361.04 (0.87–1.25)
  Per 5 kg1.02 (1.00–1.03)0.020.721.01 (0.99–1.03)0.51.02 (1.00–1.04)0.06
Colorectal cancer–specific mortality
 BMI recent
  <18.515/3880.90 (0.51–1.58)12/3131.04 (0.54–2.02)
  18.5–<25383/10,5401.00 (ref)217/6,6011.00 (ref)166/3,9391.00 (ref)
  25–<30481/11,7031.14 (0.99–1.31)172/4,3861.25 (1.01–1.55)309/7,3171.03 (0.84–1.26)
  ≥30354/7,6741.19 (1.03–1.39)0.41158/3,4221.28 (1.03–1.60)196/4,2511.09 (0.87–1.35)
  30–<35215/5,0621.12 (0.94–1.34)82/1,9391.27 (0.97–1.66)133/3,1231.02 (0.81–1.30)
  35–<4090/1,6361.36 (1.07–1.72)41/8921.20 (0.85–1.72)49/7441.53 (1.08–2.15)
  ≥4049/9751.24 (0.91–1.69)0.1535/5911.45 (0.98–2.15)14/3840.79 (0.45–1.39)
  Per 5 kg/m2d1.07 (1.02–1.13)0.0060.231.09 (1.02–1.17)0.011.04 (0.96–1.13)0.3
 BMI at age 20 y
  <18.570/2,0540.94 (0.73–1.22)53/1,5250.94 (0.69–1.27)17/5300.95 (0.57–1.58)
  18.5–<25820/21,5641.00 (ref)411/11,3191.00 (ref)409/10,2451.00 (ref)
  25–<30238/5,0641.10 (0.95–1.29)52/1,2151.05 (0.78–1.43)186/3,8491.09 (0.91–1.31)
  ≥3070/1,0981.44 (1.11–1.85)0.1831/3791.76 (1.18–2.62)39/7191.20 (0.84–1.70)
  30–<3553/8531.55 (1.16–2.07)
  ≥3517/2451.15 (0.70–1.90)0.30
  Per 5 kg/m2d1.08 (1.00–1.16)0.040.011.20 (1.06–1.36)0.0041.00 (0.91–1.10)0.99
 Adult weight changee
  Lost weight72/1,8310.93 (0.70–1.23)39/9911.10 (0.74–1.63)33/8400.83 (0.54–1.27)
  0–<6 kg244/6,0351.00 (ref)109/2,9461.00 (ref)135/3,0881.00 (ref)
  6–<10 kg201/5,0960.97 (0.80–1.18)92/2,4781.08 (0.81–1.45)109/2,6180.95 (0.73–1.24)
  10–<20 kg357/8,8731.03 (0.87–1.22)144/4,3440.95 (0.73–1.24)213/4,5291.11 (0.88–1.40)
  ≥20 kg334/8,2021.03 (0.87–1.23)0.19167/3,8581.16 (0.89–1.50)167/4,3440.94 (0.73–1.20)
  Per 5 kg1.02 (1.00–1.03)0.090.231.02 (0.99–1.05)0.11.01 (0.98–1.03)0.5
  • aAdjusted for sex, TNM stage, cigarette smoking, C-CFR study site, and age at diagnosis (strata statement).

  • bWald P value for linear trend, excluding underweight BMI.

  • cCalculated from -2 log likelihood ratio test comparing models with and without interaction terms between BMI (or weight change) and sex.

  • dUnderweight BMI (<18.5 kg/m2) not included in model.

  • eAdjusted for factors listed in “a” and additionally adjusted for BMI at age 20.