Table 5.

Multivariate-adjusteda geometric means of estrogen metabolism measures by category of tea intake

Geometric mean by tea intake
≤1–3 cups/month1–6 cups/week1 cup/day2+ cups/dayPtrend
Individual and grouped EM (pmol/mg creatinine)
Total EM210.7194.2189.6215.50.76
Parent estrogens42.340.339.444.50.79
Methylated catechols10.910.711.712.20.34
 Methylated 2-catechols10.510.411.311.80.32
  2-Hydroxyestrone-3-methyl ether1.
 Methylated 4-catechols0.
2-Hydroxylation pathway71.972.666.466.40.59
4-Hydroxylation pathway7.
16-Hydroxylation pathway67.458.660.274.00.29
Ratios (pmol/pmol)
2-Catechols/methylated 2-catechols5.
4-Catechols/methylated 4-catechols26.426.824.821.40.32
Catechols/methylated catechols6.
Parent estrogens/2-, 4-, 16-pathways0.
2-Pathway/parent estrogens1.
4-Pathway/parent estrogens0.
16-Pathway/parent estrogens1.
  • aAdjusted for age at urine collection (continuous), BMI at collection (kg/m2, continuous), height (continuous), ovulatory cycle (yes/no), first-morning urine (yes/no), quartiles of alcohol intake (nondrinker, ≤1.49, 1.50–4.85, >4.85 g/day), total physical activity (<3, 3–8.9, 9–17.9, 18–26.9, 27–41.9, ≥42 MET h/week), current tobacco use (yes/no), luteal day (≤5, 6–7, 8–9, ≥10 days to next period), usual menstrual cycle length (<26, 26–31, ≥32 days), menstrual cycle regularity (extremely regular, very regular, regular, usually/always irregular), and age at first birth and parity (nulliparous, age at first birth <25 years/1–2 children, age at first birth 25–29 years/1–2 children, age at first birth ≥30 years/1–2 children, age at first birth <25 years/≥3 children, age at first birth ≥25 years/≥3 children). Numbers do not sum to 603 due to missing values for exposure. Significant Ptrend shown in bold.