Table 5.

Multivariate-adjusteda geometric means of estrogen metabolism measures by category of tea intake

Geometric mean by tea intake
≤1–3 cups/month1–6 cups/week1 cup/day2+ cups/dayPtrend
N415805036
Individual and grouped EM (pmol/mg creatinine)
Total EM210.7194.2189.6215.50.76
Parent estrogens42.340.339.444.50.79
 Estrone27.926.625.527.70.66
 Estradiol13.613.213.215.40.17
Catechols69.770.062.661.50.35
 2-catechols59.960.754.052.50.38
  2-Hydroxyestrone52.853.847.945.90.39
  2-Hydroxyestradiol6.16.05.65.50.29
 4-catechols
  4-Hydroxyestrone6.46.65.76.40.79
Methylated catechols10.910.711.712.20.34
 Methylated 2-catechols10.510.411.311.80.32
  2-Methoxyestrone8.18.28.88.70.63
  2-Methoxyestradiol0.720.720.660.750.80
  2-Hydroxyestrone-3-methyl ether1.41.21.41.40.80
 Methylated 4-catechols0.260.230.240.270.76
  4-Methoxyestrone0.170.160.150.180.82
  4-Methoxyestradiol0.060.050.060.050.66
2-Hydroxylation pathway71.972.666.466.40.59
4-Hydroxylation pathway7.47.06.87.30.88
16-Hydroxylation pathway67.458.660.274.00.29
 16α-Hydroxyestrone11.69.410.210.70.83
 Estriol28.926.725.534.70.13
17-Epiestriol1.61.71.62.40.01
 16-Ketoestradiol14.012.411.515.50.48
 16-Epiestriol5.95.25.56.30.44
Ratios (pmol/pmol)
2-Hydroxyestrone/16α-hydroxyestrone4.45.64.94.10.76
4-Pathway/2-pathway0.100.100.090.100.62
2-Pathway/16-pathway1.051.11.10.860.20
2,4-Pathway/16-pathway0.100.120.120.080.26
2-Catechols/methylated 2-catechols5.75.54.84.40.02
4-Catechols/methylated 4-catechols26.426.824.821.40.32
Catechols/methylated catechols6.36.25.45.00.02
Parent estrogens/2-, 4-, 16-pathways0.270.270.280.280.85
2-Pathway/parent estrogens1.71.71.71.50.34
4-Pathway/parent estrogens0.170.170.170.150.36
16-Pathway/parent estrogens1.61.51.51.70.39
  • aAdjusted for age at urine collection (continuous), BMI at collection (kg/m2, continuous), height (continuous), ovulatory cycle (yes/no), first-morning urine (yes/no), quartiles of alcohol intake (nondrinker, ≤1.49, 1.50–4.85, >4.85 g/day), total physical activity (<3, 3–8.9, 9–17.9, 18–26.9, 27–41.9, ≥42 MET h/week), current tobacco use (yes/no), luteal day (≤5, 6–7, 8–9, ≥10 days to next period), usual menstrual cycle length (<26, 26–31, ≥32 days), menstrual cycle regularity (extremely regular, very regular, regular, usually/always irregular), and age at first birth and parity (nulliparous, age at first birth <25 years/1–2 children, age at first birth 25–29 years/1–2 children, age at first birth ≥30 years/1–2 children, age at first birth <25 years/≥3 children, age at first birth ≥25 years/≥3 children). Numbers do not sum to 603 due to missing values for exposure. Significant Ptrend shown in bold.