Table 2.

Colorectal cancer subsites in ever and never OC users among 88,691 NHSI and 93,080 NHSII participants

	Cases		HR (95% CI)
				Age-adjusted	Multivariable^a
	Never-users	Ever-users	Never-users	Ever-users	Ever-users
	NHSI
Colorectal	1,079	685	ref.	0.97 (0.87–1.08)	1.01 (0.91–1.12)
Colon	844	541	ref.	1.01 (0.89–1.13)	1.04 (0.93–1.18)
Proximal colon	493	330	ref.	1.10 (0.94–1.27)	1.14 (0.98–1.32)
Distal colon	326	195	ref.	0.88 (0.72–1.07)	0.91 (0.75–1.11)
Rectum	235	144	ref.	0.85 (0.68–1.06)	0.89 (0.71–1.12)
	NHSII
Colorectal	29	177	ref.	0.98 (0.66–1.46)	1.03 (0.69–1.53)
Colon	21	118	ref.	0.88 (0.55–1.39)	0.91 (0.57–1.46)
Proximal colon	14	54	ref.	0.60 (0.33–1.09)	0.63 (0.35–1.15)
Distal colon	7	62	ref.	1.37 (0.62–2.99)	1.44 (0.66–3.16)
Rectum	8	59	ref.	1.27 (0.61–2.66)	1.35 (0.64–2.85)

↵^aAdjusted for age, BMI, height, physical activity, smoking, processed and red meat, folate, calcium, total energy, aspirin use, alcohol, age at first birth, parity, HT use, family history, and previous endoscopy screening.