Table 1.

Association of genotypes with MPM (N = 1,206) compared with SPM (N = 2,469) in the GEM Study

Additive model
ChromosomeGene neighborhoodSNPa/APer allele OR (95% CI)aP
1ARNTrs7412746C/T0.97 (0.87–1.08)0.56
1PARP1rs3219090A/G0.90 (0.80–1.01)0.07
1PARP1rs2695238C/G0.96 (0.85–1.07)0.43
1NID1rs3768080G/A0.94 (0.85–1.05)0.25
1NID1rs10754833C/T0.93 (0.84–1.04)0.20
2CASP8rs6735656bG/T1.08 (0.96–1.22)0.21
2CASP8rs13016963A/G1.10 (0.99–1.22)0.09
5TERTrs2242652T/C1.04 (0.91–1.18)0.60
5TERTrs2853676A/G1.07 (0.95–1.19)0.28
5TERTrs13356727G/A1.10 (0.98–1.22)0.10
5TERT;CLPTM1Lrs4975616G/A1.06 (0.94–1.18)0.34
5TERT;CLPTM1Lrs401681T/C1.14 (1.02–1.26)0.02
5SLC45A2rs16891982C/G0.71 (0.45–1.12)0.14
5SLC45A2rs35391T/C0.70 (0.39–1.28)0.25
5SLC45A2rs26722T/C0.66 (0.36–1.23)0.19
5SLC45A2rs13289G/C0.99 (0.88–1.10)0.81
6IRF4rs12203592T/C1.10 (0.97–1.24)0.14
6IRF4rs872071A/G0.96 (0.86–1.07)0.43
9TYRP1rs1408799T/C0.90 (0.80–1.01)0.07
9TYRP1rs2733832C/T0.87 (0.78–0.97)0.01
9MTAPrs2218220T/C0.88 (0.79–0.98)0.02
9MTAPrs1335510cG/T0.82 (0.73–0.91)0.0003
9MTAPrs7023329G/A0.87 (0.78–0.96)0.008
9MTAPrs10811629G/A0.85 (0.76–0.94)0.002
11CCND1rs11604821G/A1.03 (0.92–1.15)0.64
11CCND1rs1485993T/C1.03 (0.92–1.15)0.57
11CCND1rs11263498T/C1.01 (0.91–1.13)0.82
11TYRrs1042602A/C0.91 (0.82–1.02)0.11
11TYRrs10765198C/T1.22 (1.10–1.36)0.0003
11TYRrs1847142A/G1.21 (1.09–1.35)0.0004
11TYRrs10830253cG/T1.23 (1.10–1.37)0.0002
11ATMrs12278954dA/C0.91 (0.78–1.05)0.20
15OCA2rs1800407A/G1.10 (0.92–1.32)0.29
15OCA2rs1800401T/C1.11 (0.86–1.42)0.43
15HERC2rs1129038G/A0.99 (0.87–1.13)0.88
15HERC2rs12913832A/G1.00 (0.88–1.13)0.97
20ASIPrs17305657C/T1.12 (0.95–1.33)0.18
20ASIPrs4911414T/G1.10 (0.99–1.23)0.08
20PIGUrs910873A/G1.16 (0.99–1.36)0.07
20PIGUrs17305573C/T1.15 (0.96–1.36)0.12
20NCOA6rs4911442G/A1.19 (1.03–1.38)0.02
20MYH7Brs1885120C/G1.15 (0.97–1.36)0.11
20LOC647979rs1204552A/T1.10 (0.91–1.32)0.32
21MX2rs45430G/A0.87 (0.77–0.97)0.01
22PLA2G6rs6001027G/A1.03 (0.92–1.16)0.61
22PLA2G6rs132985T/C0.96 (0.87–1.07)0.51
22PLA2G6rs738322G/A0.95 (0.85–1.06)0.35

NOTE: Limited to Caucasians. Bold type indicates P values < 0.05.

Abbreviations: a, minor allele; A, major allele.

  • aAdjusted for age at diagnosis, sex, age by sex, and study center.

  • brs6735656 is a proxy for rs10931936 (r2 = 0.965).

  • cThe MTAP and TYR loci each had more than one SNP with a significant association (P < 0.05). SNPs with the strongest association in stepwise logistic regression models are noted.

  • drs12278954 is a proxy for rs1801516 (r2 = 1.00).