Table 2.

Folate pathway polymorphisms in the child and parents and the risk of CBT

Child case–control (n = 321/552)aCase–parent trios (n = 246)aMother case–control (n = 318/558)aFather case–control (n = 261/483)a
PolymorphismGenotypen cases/controlsORb (95% CI)OR (95% CI)n cases/controlsORb (95% CI)n cases/controlsORb (95% CI)
MTHFR 677C>TCC143/2281.0 (Reference)1.00 (Reference)129/2451.0 (Reference)105/2061.0 (Referent)
CT144/2530.95 (0.70–1.29)0.87 (0.62–1.22)151/2511.20 (0.88–1.63)123/2091.22 (0.87–1.72)
TT32/640.83 (0.51–1.36)0.64 (0.36–1.12)34/511.40 (0.84–2.32)31/601.10 (0.65–1.85)
CT/TT176/3170.93 (0.69–1.24)0.84 (0.60–1.18)185/3021.23 (0.92–1.65)154/2691.19 (0.86, 1.65)
MTHFR 1298A>CAA159/2731.0 (Reference)1.00 (Reference)166/2511.0 (Reference)117/2431.0 (Referent)
AC129/2270.95 (0.70–1.28)1.17 (0.83–1.65)126/2490.72 (0.53–0.98)122/1801.30 (0.93–1.82)
CC32/421.24 (0.73–2.09)0.93 (0.51–1.71)25/490.81 (0.47–1.40)20/510.81 (0.45, 1.46)
AC/CC161/2690.99 (0.74–1.32)1.15 (0.82–1.62)151/2980.74 (0.55–0.98)142/2311.19 (0.86, 1.64)
MTRR 66A>GAA80/1021.0 (Reference)1.00 (Reference)66/1181.0 (Reference)67/761.0 (Referent)
AG148/2640.77 (0.53–1.11)0.96 (0.66–1.40)159/2451.25 (0.85–1.83)124/2420.60 (0.40, 0.91)
GG90/1750.71 (0.48–1.07)0.63 (0.37–1.06)88/1800.94 (0.62–1.42)66/1490.54 (0.34, 0.87)
AG/GG238/4390.75 (0.53–1.06)0.91 (0.63–1.33)247/4251.12 (0.78–1.61)190/3910.58 (0.39, 0.86)
CBS 2199T>CTT88/1711.0 (Reference)1.00 (Reference)98/1701.0 (Reference)80/1301.0 (Referent)
TC150/2461.16 (0.83–1.64)1.42 (0.95–2.14)143/2670.91 (0.65–1.27)131/2450.81 (0.56, 1.17)
CC80/1231.30 (0.87–1.93)2.01 (1.20–3.38)72/1071.12 (0.75, 1.68)47/930.82 (0.52, 1.32)
TC/CC230/3691.21 (0.88–1.66)1.49 (1.00–2.23)215/3740.97 (0.71–1.33)178/3380.81 (0.57, 1.15)
MTR 2756A>GAA214/3561.0 (Reference)1.00 (Reference)214/3401.0 (Reference)167/3111.0 (Referent)
AG96/1650.93 (0.68–1.27)0.90 (0.63–1.30)91/1800.80 (0.58–1.09)76/1460.90 (0.63–1.29)
GG9/260.58 (0.26–1.30)0.84 (0.33–2.14)10/280.55 (0.25–1.18)16/162.04 (0.96–4.30)
AG/GG105/1910.88 (0.65–1.19)0.90 (0.63–1.30)101/2080.76 (0.56–1.03)92/1621.01 (0.72, 1.41)
MTR 5049C>ACC141/2091.0 (Reference)1.00 (Reference)120/2171.0 (Reference)105/1581.0 (Referent)
CA129/2600.75 (0.54–1.02)0.82 (0.57–1.18)150/2591.03 (0.76–1.42)117/2370.77 (0.55–1.10)
AA49/761.16 (0.75–1.79)0.81 (0.48–1.37)45/711.34 (0.85–2.10)38/750.76 (0.47, 1.24)
CA/AA178/3360.83 (0.62–1.12)0.82 (0.57–1.17)195/3301.09 (0.81–1.47)155/3120.77 (0.55, 1.07)
  • aNumbers are maximum available with genotyping data—sample fails or deletions due to Mendelian inconsistency may result in lower total for individual polymorphisms.

  • bORs adjusted for child's sex, age, State of residence, year of birth, ethnic group, maternal (paternal) age, and maternal education.