Table 3.

ORs for maternal folic acid supplementation pre-pregnancy and risk of CBT by folate pathway genotypes of child and mother

Child genotypeMother genotype
N cases/controlsN cases/controls
PolymorphismNo folic acidcFolic acidORa (95% CI)PinteractionbNo folic acidcFolic acidORa (95% CI)Pinteractionb
MTHFR 677C>T
CC100/11643/1120.47 (0.29–0.78)0.3391/13538/1100.60 (0.37–0.98)0.14
CT100/15644/970.87 (0.54–1.41)108/14143/1100.52 (0.31–0.85)
TT25/447/200.33 (0.09–1.21)22/3812/131.32 (0.33–5.34)
CT/TT125/20051/1170.82 (0.54–1.27)0.16130/17955/1230.65 (0.42–1.00)0.51
MTHFR 1298A>C
AA113/16046/1130.68 (0.43–1.07)0.98116/14750/1040.68 (0.43–1.07)0.79
AC93/11336/940.60 (0.36–1.01)93/14233/1070.46 (0.27–0.78)
CC20/2112/210.53 (0.15–1.93)15/2510/240.78 (0.23–2.67)
AC/CC113/15448/1150.59 (0.37–0.95)0.97108/16743/1310.53 (0.33–0.84)0.61
MTRR 66A>G
AA52/6628/360.89 (0.44–1.79)0.1842/7224/461.00 (0.47–2.11)0.02
AG109/15339/1110.54 (0.33–0.88)109/14450/1010.80 (0.50–1.28)
GG64/9626/790.50 (0.27–0.94)70/9518/850.26 (0.14–0.51)
AG/GG173/24965/1900.57 (0.39–0.83)0.07179/23968/1860.54 (0.38–0.78)0.10
CBS 2199T>C
TT60/9328/780.64 (0.35–1.18)0.9768/8930/810.56 (0.31–1.00)0.31
TC106/14644/1000.62 (0.38–1.01)103/15240/1150.58 (0.36–0.93)
CC58/7422/490.59 (0.28–1.23)49/6923/381.03 (0.49–2.17)
TC/CC164/22066/1490.65 (0.44–0.96)0.95152/22163/1530.68 (0.46–1.00)0.68
MTR 2756A>G
AA151/20063/1560.62 (0.42–0.92)0.94149/18565/1550.53 (0.36–0.80)0.74
AG69/10327/620.72 (0.39–1.34)67/10924/710.64 (0.35–1.19)
GG6/133/13– (–)7/183/10– (–)
AG/GG75/11630/750.71 (0.40–1.26)0.7774/12727/810.71 (0.40–1.28)0.46
MTR 5049C>A
CC103/12138/880.53 (0.32–0.89)0.6085/12135/960.57 (0.34–0.97)0.98
CA89/15440/1060.77 (0.47–1.27)107/15143/1080.65 (0.40–1.05)
AA33/3916/370.56 (0.23–1.39)30/4015/310.59 (0.23–1.51)
CA/AA122/19356/1430.72 (0.47–1.10)0.40137/19158/1390.65 (0.43–0.98)0.90
  • aORs adjusted for child's sex, age, State of residence, year of birth, ethnic group, maternal age, and maternal education.

  • bP value of polymorphism by folic acid interaction term in a model where main effects accounted for.

  • c“No folate” prepregnancy is the reference for all ORs.