Table 3.

Genotype and haplotype associations with MPM (N = 1,074) compared with SPM (N = 2,137) for participants with no missing data in the GEM Study

Gene neighborhoodSNP(s)ModelOR (95% CI)aPOR (95% CI)bPOR (95% CI)cP
Genotypes
TERT;CLPTM1Lrs401681ADD1.21 (1.08–1.35)0.0011.20 (1.07–1.35)0.00061.19 (1.06–1.33)0.004
TYRP1rs2733832ADD0.83 (0.74–0.94)0.00200.85 (0.75–0.95)0.00090.85 (0.76–0.96)0.006
MTAPrs1335510ADD0.80 (0.71–0.89)0.000100.80 (0.71–0.90)0.00040.81 (0.72–0.91)0.0005
TYRrs10830253ADD1.23 (1.09–1.38)0.00051.19 (1.06–1.33)0.0031.20 (1.06–1.34)0.003
NCOA6rs4911442ADD1.18 (1.01–1.38)0.031.16 (0.99–1.35)0.071.16 (0.99–1.35)0.06
MX2rs45430ADD0.87 (0.77–0.97)0.020.87 (0.77–0.98)0.020.85 (0.75–0.96)0.008
Haplotype
PARP1rs3219090; rs2695238ACd0.97 (0.85–1.09)0.99 (0.87–1.12)0.99 (0.88–1.13)
PARP1rs3219090; rs2695238AGd0.52 (0.29–0.92)0.140.55 (0.31–0.97)0.220.55 (0.31–0.97)0.22
PARP1rs3219090; rs2695238GCd1.13 (0.64–1.97)1.09 (0.62–1.91)1.10 (0.62–1.95)

NOTE: Participants were included who had no missing data for phenotypic index, back nevus counts, or genotypes or haplotypes included in the table.

Abbreviation: ADD, additive.

  • aAdjusted for age at diagnosis, sex, age by sex, and study center.

  • bAdjusted for age at diagnosis, sex, age by sex, study center, phenotypic index, and back nevi (0–10, >10).

  • cAdjusted for age at diagnosis, sex, age by sex, study center, phenotypic index, back nevi (0–10, >10), and all genotypes/haplotypes in the table.

  • dReference category determined by the haplotype with the highest frequency.