Table 4.

Differential methylation in PBLs of AA versus non-AA cases in the CBCS

CpG probeAA mean β (n = 29)Non-AA mean β (n = 40)Delta βUnadjusted P valueAdjusted P valueaOverlapping variant
DSC2_E90_F0.47210.29040.1817<0.0001<0.0001None
KCNK4_E3_F0.52030.41440.1059<0.0001<0.0001None
GSTM1_P266_F0.32520.4637−0.13850.0040.01None
TUSC3_E29_R0.15520.10400.05120.0010.001None
SMARCA3_P17_R0.10790.08980.01810.0030.002None
IMPACT_P234_R0.09720.07270.02450.0010.001None
RAF1_P330_F0.09010.1105−0.02040.430.19None
HBII-52_E142_F0.59300.7702−0.17720.0001<0.0001None
AXL_P223_R0.66990.53060.1393<0.0001<0.0001SNPb
DNAJC15_E26_R0.13080.1582−0.02740.0003<0.0001SNPb
DNAJC15_P65_F0.94270.9565−0.01380.0003<0.0001SNP
TES_P182_F0.16420.14390.02030.100.05SNPb

Comparison of transformed β values in AAs versus non-AAs was performed using the t test.

  • aAdjusted for age and menopausal status.

  • bProbe overlaps one SNP, but impact may be negligible due to SNP location at end of probe, rarity of the minor allele, and/or no appreciable difference in population (African vs. European) frequencies reported.