Table 3.

Selected risk factors among patients with oropharygneal cancer from KPNC, 2007–2010

A. HPV-related oropharyngeal cancer sitesa
Any HPV-relatedTongue (HPV+)TonsilOropharynx
RRb (95% CI)PRRb (95% CI)PRRb (95% CI)PRRb (95% CI)P
Year (per 1 year)1.05 (0.97–1.14)0.251.03 (0.92–1.17)0.5931.07 (0.95–1.20)0.2851.04 (0.76–1.41)0.816
Age (per 10 years)1.53 (1.44–1.62)<0.0011.62 (1.49–1.77)<0.0011.43 (1.31–1.55)<0.0011.71 (1.36–2.14)<0.001
Male sex5.34 (4.18–6.83)<0.0015.90 (4.06–8.56)<0.0015.90 (4.07–8.56)<0.0012.03 (0.98–4.20)0.056
Smokingc2.12 (1.73–2.58)<0.0011.95 (1.46–2.62)<0.0012.10 (1.57–2.82)<0.0013.84 (1.74–8.50)<0.001
Alcohol abusec2.20 (1.76–2.75)<0.0011.90 (1.35–2.68)<0.0012.43 (1.76–3.36)<0.0012.70 (1.26–5.82)0.011
B. HPV-unrelated oropharyngeal cancer sitesa
Any HPV-unrelatedTongue (HPV)Mouth
RRb (95% CI)PRRb (95% CI)PRRb (95% CI)P
Year (per 1 year)0.98 (0.90–1.08)0.7501.04 (0.91–1.18)0.5810.93 (0.81–1.06)0.279
Age (per 10 years)1.71 (1.60–1.83)<0.0011.58 (1.45–1.73)<0.0011.91 (1.72–2.13)<0.001
Male sex1.20 (0.97–1.47)0.0921.16 (0.88–1.54)0.3011.23 (0.90–1.68)0.186
Smokingc2.08 (1.66–2.61)<0.0011.58 (1.17–2.15)0.0032.98 (2.11–4.22)<0.001
Alcohol abusec2.42 (1.88–3.12)<0.0011.90 (1.31–2.77)<0.0013.08 (2.18–4.37)<0.001
  • aDefined by histologic site of cancer as described by Chaturvedi et al. (17).

  • bRate ratios from multivariable Poisson Regression model adjusted for all variables in table.

  • cCorresponds to smoking or alcohol abuse diagnosis in prior 2 years.