Table 2.

Change in characteristics of patients with oropharyngeal cancer from KPNC between 1995 and 2010

Calendar year of cancer diagnosis
Characteristic199519982001200420072010P-trenda
A. HPV-related sitesb
 Total cases52557111496126
 Mean age, years62.859.460.860.660.060.90.40
 Male sex, %65.467.369.083.381.380.2<0.001
 White race, %90.470.991.686.882.384.10.88
 Prior smoking, %55.245.20.046
 Prior alcohol abuse, %22.924.60.98
 Lower education census-tract, %17.524.513.015.024.018.20.82
 Lower income census-tract, %2.55.74.42.84.23.30.97
B. HPV-unrelated sitesb
 Total cases778291829595
 Mean age, years65.063.466.165.065.062.20.71
 Male sex, %55.857.353.961.052.650.50.23
 White race, %81.884.282.478.177.972.60.033
 Prior smoking, %61.148.40.070
 Prior alcohol abuse, %30.520.00.10
 Lower education census-tractc, %17.426.318.814.614.716.50.15
 Lower income census-tractd, %8.79.23.58.54.22.20.13
  • NOTE: Findings in bold are statistically significant.

  • aP-trend based on linear regression for age and logistic regression for remaining variables, with calendar year as the predictor.

  • bDefined by histologic site of cancer as described by Chaturvedi et al. (17).

  • cLower education census-tract defined as ≥25% population with less than a high school education.

  • dLower income census-tract defined as ≥20% population with household income below poverty levels.