Table 2.

Multivariable RRs of colorectal cancer according to body fatness at childhood and adolescence in the NHS and the HPFS (1988–2010)

Somatotype 1Somatotype 2–<3Somatotype 3–<4Somatotype 4–<5Somatotype 5+Ptrendc
Women (NHS)
 Cases, n512309215144112
 Body fatness at childhood, MVa1 (Reference)1.11 (0.96–1.28)1.03 (0.87–1.20)1.10 (0.91–1.31)1.32 (1.08–1.63)0.03
 Body fatness at childhood, MV+BMIb1 (Reference)1.10 (0.96–1.27)1.01 (0.86–1.19)1.07 (0.88–1.29)1.28 (1.04–1.58)d0.08
 Cases, n35039528416499
 Body fatness at adolescence, MVa1 (Reference)1.01 (0.88–1.17)1.05 (0.90–1.23)1.02 (0.85–1.23)1.33 (1.06–1.67)0.08
 Body fatness at adolescence, MV+BMIb1 (Reference)1.00 (0.87–1.16)1.03 (0.87–1.20)0.99 (0.82–1.19)1.27 (1.01–1.60)d0.23
Men (HPFS)
 Cases, n32118212184100
 Body fatness at childhood, MVa1 (Reference)1.01 (0.83–1.21)0.99 (0.80–1.22)1.01 (0.79–1.29)1.12 (0.89–1.41)0.48
 Body fatness at childhood, MV+BMIb1 (Reference)1.00 (0.83–1.21)0.95 (0.79–1.20)0.96 (0.75–1.22)1.04 (0.82–1.31)d0.97
 Cases, n1722791719195
 Body fatness at adolescence, MVa1 (Reference)0.99 (0.82–1.20)0.97 (0.78–1.20)0.80 (0.62–1.04)1.11 (0.86–1.44)0.79
 Body fatness at adolescence, MV+BMIb1 (Reference)0.96 (0.79–1.16)0.91 (0.74–1.14)0.73 (0.56–0.95)0.98 (0.75–1.27)d0.20
  • aMultivariable RRs were adjusted for age (in month), and height (continuous), smoking before age 30 (0, 1–4, 5–10, or >10 pack-years), history of colorectal cancer in a parent or sibling (yes or no), history of sigmoidoscopy/endoscopy (yes or no), current physical activity (<3, 3–< 27, 27+ MET-h/wk), regular aspirin use (yes or no), multivitamin use (yes or no), alcohol consumption (0–<5, 5–<10, 10–<15, or ≥15 g/d), current energy-adjusted total intake of calcium, vitamin D, folate, red meat, processed meat (all in tertiles), and postmenopausal hormone use (premenopausal, never, past, or current user; women only).

  • bFurther adjustment for adult BMI (<25, 25–<27.5, 27.5–< 30, ≥30 kg/m2).

  • cUsing ordinal variables of somatotype, original 9 categories.

  • dP values for heterogeneity by sex were 0.19 for body fatness at childhood and 0.14 for body fatness at adolescence.