Table 4.

Stratum-specific multivariablea RRs of colorectal cancer in the NHS and HPFS

WomenMen
ChildhoodBMI at age 18ChildhoodBMI at age 21d
Somatotype 1Somatotype ≥ 5P15–<1927.5–<45PSomatotype 1Somatotype ≥ 4P15–<1927.5-<45P
Birth weight (pounds)b
 <71 (Reference)1.12 (0.64–1.96)0.241 (Reference)2.10 (1.26–3.50)0.961 (Reference)0.84 (0.56–1.23)0.351 (Reference)1.68 (1.08–2.60)0.71
 ≥71.06 (0.83–1.35)1.83 (1.33–2.51)1.51(0.73–3.12)2.39 (1.50–3.81)1.24 (0.82–1.89)1.49 (0.98–2.25)1.65(0.99–2.76)1.63 (0.94–2.82)
Height, m
 <Medianc1 (Reference)0.99 (0.71–1.38)0.031 (Reference)1.20(0.88–1.62)0.181 (Reference)1.03 (0.81–1.32)0.991 (Reference)1.19 (0.72–1.96)0.59
 ≥Median1.14 (0.96–1.36)1.78 (1.36–2.33)1.14 (0.80–1.62)1.65 (1.17–2.33)1.10 (0.88–1.38)1.07 (0.81–1.41)1.27 (0.75–2.12)1.19 (0.58–2.44)
Family history of colorectal cancer
 No1 (Reference)1.28 (1.01–1.62)0.881 (Reference)1.24 (0.98–1.56)0.481 (Reference)0.97 (0.78–1.19)0.931 (Reference)1.15 (0.84–1.59)0.41
 Yes1.36 (1.10–1.68)1.73 (1.14–2.63)1.23 (0.92–1.63)2.14 (1.36–3.35)1.38 (1.02–1.86)1.64 (1.15–2.34)1.14 (0.79–1.65)1.69 (0.93–3.06)
Adult physical activity (MET-h/wk)
 <91 (Reference)1.26 (0.91–1.75)0.931 (Reference)1.27 (0.96–1.68)0.531 (Reference)0.88 (0.60–1.29)0.221 (Reference)1.31 (0.76–2.28)0.10
 ≥90.94 (0.79–1.12)1.21 (0.92–1.61)1.25 (0.90–1.73)1.20 (0.83–1.74)1.09 (0.84–1.42)1.13 (0.85–1.50)1.43 (0.77–2.62)1.21 (0.71–2.06)
Adult BMI (kg/m2)
 <251 (Reference)1.18 (0.85–1.66)0.391 (Reference)1.08 (0.73–1.601)0.131 (Reference)0.89 (0.64–1.23)0.391 (Reference)1.10 (0.68–1.77)0.68
 ≥251.01 (0.84–1.21)1.41 (1.09–1.83)0.91 (0.43–1.94)1.58 (1.22–2.03)1.25 (1.00–1.56)1.37 (1.08–1.69)1.23 (0.72–2.10)1.69 (1.06–2.72)
  • aWe adjusted for the same covariates as those listed in Table 2 footnote 2 except for the factors examined here.

  • bBirth weight was assessed in 1992 in the NHS (n = 695 cases) and in 1994 in the HPFS (n = 312 cases).

  • cCutoffs were 1.65 m for women and 1.78 m for men.

  • d15–<20.4, 24.9–<45 kg/m2 were used for the joint analysis on birth weight and BMI at 21 years in men due to small number of cases.