Table 3.

Multivariable RRs of colorectal cancer according to BMI (kg/m2) at age 18 in the NHS and at age 21 in the HPFS (1988–2010)

15–<1919–<20.420.4–<21.921.9–<24.924.9–<27.527.5–<45 kg/m2Ptrendc
Women (NHS)
 Cases, n1992392922909664
 MVa1 (Reference)1.01 (0.84–1.22)1.09 (0.91–1.30)1.12 (0.94–1.35)1.31 (1.03–1.68)1.53 (1.15–2.04)<0.001
 MV + BMIb1 (Reference)1.01 (0.83–1.22)1.07 (0.89–1.29)1.09 (0.90–1.32)1.25 (0.97–1.62)1.44 (1.06–1.95)d0.002
Men (HPFS)
 Cases, n8310013328213476
 MVa1 (Reference)1.15 (0.85–1.55)1.20 (0.90–1.59)1.22 (0.93–1.58)1.17 (0.86–1.56)1.20 (0.86–1.68)0.56
 MV + BMIb1 (Reference)1.17 (0.87–1.58)1.20 (0.91–1.60)1.22 (0.94–1.58)1.15 (0.86–1.55)1.18 (0.84–1.65)d0.71
15–<18.518.5–<23.023.0–<25.025.0–<27.527.5–<3030–<45 kg/m2Ptrendc
Women (NHS)
 Cases, n131743152903133
 MVa1 (Reference)1.06 (0.88–1.28)1.21 (0.95–1.53)1.33 (1.01–1.74)1.43 (0.95–2.10)1.71 (1.16–2.51)<0.001
 MV + BMIb1 (Reference)1.05 (0.88–1.26)1.16 (0.91–1.48)1.26 (0.95–1.67)1.33 (0.89–2.00)1.60 (1.07–2.39)e0.009
Men (HPFS)
 Cases, n613461901334729
 MVa1 (Reference)1.10 (0.84–1.46)1.14 (0.84–1.53)1.09 (0.79–1.51)1.13 (0.76–1.69)1.11 (0.70–1.76)0.44
 MV + BMIb1 (Reference)1.11 (0.84–1.47)1.13 (0.84–1.52)1.08 (0.78–1.49)1.12 (0.75–1.67)1.08 (0.69–1.72)e0.57
  • aMultivariable RRs were adjusted for age (in month), and height (continuous), smoking before age 30 (0, 1–4, 5–10, or >10 pack-years), history of colorectal cancer in a parent or sibling (yes or no), history of sigmoidoscopy/endoscopy (yes or no), current physical activity (<3, 3–< 27, 27+ MET-h/wk), regular aspirin use (yes, no), multivitamin use (yes or no), alcohol consumption (0–<5, 5–<10, 10–<15, or ≥15 g/d), current energy-adjusted total intake of calcium, vitamin D, folate, red meat, processed meat (all in tertiles), and postmenopausal hormone use (premenopausal, never, past, or current user; women only).

  • bFurther adjustment for adult BMI (<25, 25–<27.5, 27.5–<30, ≥30 kg/m2).

  • cContinuous values of young adult BMI were used to calculate the Ptrend.

  • dPheterogeneity by sex was 0.39.

  • ePheterogeneity by sex was 0.21.