Table 1.

Characteristics of lung cancer patients by statin use before and after diagnosis

Statin use in year before diagnosisaStatin use in year after diagnosisbStatin use after diagnosisb
Ever n (%)Never (%)User n (%)Nonuser (%)User n (%)Nonuser (%)
Characteristics(n = 13,398)(n = 3,638)(n = 3,638)
Year of diagnosis
 1998–2000102 (3)2,204 (22)24 (3)618 (22)79 (7)563 (22)
 2001–2003451 (14)2,893 (29)132 (15)754 (27)217 (19)669 (26)
 2004–20061,118 (34)2,650 (26)279 (32)690 (25)347 (31)622 (25)
 2007–20091,616 (49)2,362 (23)428 (50)713 (26)472 (42)669 (27)
Age at diagnosis
 <5016 (0)405 (4)7 (1)166 (6)14 (1)159 (6)
 50–59230 (7)1,363 (13)84 (10)486 (18)132 (12)438 (17)
 60–69966 (29)2,607 (26)295 (34)873 (31)377 (34)791 (31)
 70–791,447 (44)3,447 (34)360 (42)897 (32)451 (40)806 (32)
 80–89598 (18)2,045 (20)115 (13)325 (12)137 (12)303 (12)
 ≥9030 (1)242 (2)2 (0)28 (1)4 (0)26 (1)
Gender, males2,030 (62)5,886 (58)541 (63)1,563 (56)690 (62)1,414 (56)
Treatment within 6 months of cancer diagnosis
 Surgeryc339 (13)883 (11)212 (31)659 (31)333 (38)538 (28)
 Chemotherapy743 (23)2,287 (23)267 (31)993 (36)324 (29)936 (37)
 Radiotherapy1,028 (31)3,197 (32)319 (37)1,062 (38)377 (34)1,004 (40)
Histology
 Non–small cell1,901 (58)5,627 (56)638 (74)1,982 (71)835 (75)1,785 (71)
 Small cell418 (13)1,257 (12)89 (10)335 (12)108 (10)316 (13)
 Missing968 (29)3,225 (32)136 (16)458 (17)172 (15)422 (17)
Smoking status before cancer diagnosis
 Non-smoker372 (11)1,338 (13)100 (12)385 (14)128 (11)357 (14)
 Ex-smoker1,688 (51)3,175 (31)439 (51)955 (34)525 (47)869 (34)
 Current smoker1,149 (35)4,305 (43)295 (34)1,144 (41)411 (37)1,024 (41)
 Missing78 (2)1,291 (13)29 (3)291 (10)51 (5)269 (11)
Alcohol consumption before diagnosis
 Never564 (17)1,271 (13)132 (15)340 (12)165 (15)307 (12)
 Ever2,175 (66)5,709 (56)586 (68)1,671 (60)750 (67)1,507 (60)
 Missing548 (17)3,129 (31)145 (17)764 (28)200 (18)709 (28)
BMI (kg/m2) before diagnosis, mean (SD)26.4 (5.0)24.8 (4.8)26.8 (4.9)25.2 (4.7)26.6 (4.9)25.1 (4.7)
 Underweight (<18.5)119 (4)510 (5)23 (3)109 (4)29 (3)103 (4)
 Normal (18.5–25)1,074 (33)3,451 (34)257 (30)980 (35)336 (30)901 (36)
 Overweight (25–30)1,124 (34)2,244 (22)296 (34)722 (26)378 (34)640 (25)
 Obese (>30)598 (18)946 (9)175 (20)299 (11)214 (19)260 (10)
 Missing372 (11)2,958 (27)112 (13)665 (24)158 (14)619 (25)
Deprivation fifth
 1st (least deprived)552 (17)1,786 (17)154 (18)536 (19)201 (18)489 (19)
 2nd638 (19)1,945 (25)160 (19)527 (19)204 (18)483 (19)
 3rd648 (20)2,080 (21)166 (19)557 (20)213 (19)510 (20)
 4th712 (22)2,194 (22)185 (21)621 (22)243 (22)563 (22)
 5th (most deprived)725 (22)2,070 (20)195 (23)528 (19)251 (23)472 (19)
 Missing12 (0)33 (0)3 (0)6 (0)3 (0)6 (0)
Comorbidity before cancer diagnosis
 Cerebrovascular disease552 (17)697 (7)106 (12)140 (5)125 (11)121 (5)
 Chronic pulmonary disease871 (27)2,517 (25)226 (26)703 (25)296 (27)633 (25)
 Congestive heart disease307 (9)593 (6)64 (7)98 (4)72 (6)90 (4)
 Diabetes854 (12)600 (6)203 (24)132 (5)230 (21)105 (4)
 Myocardial infarction817 (25)368 (4)186 (22)106 (4)210 (19)82 (3)
 Peptic ulcer disease263 (8)743 (7)58 (7)188 (7)79 (7)167 (7)
 Peripheral vascular disease695 (21)677 (7)173 (20)161 (6)194 (17)140 (6)
 Renal disease480 (15)358 (4)98 (11)99 (4)111 (10)86 (3)
Other medication use after diagnosis
 Low-dose aspirin used2,109 (64)1,770 (18)550 (64)620 (22)710 (64)460 (18)
 Beta-blocker used1,050 (32)1,090 (11)310 (36)378 (14)407 (37)281 (11)
  • aAnalysis includes lung cancer patients who have more than 1 year of records before diagnosis.

  • bAnalysis includes lung cancer patients who live more than 1 year after diagnosis.

  • cExcluding cancer patients from Thames Registry as surgery information not available.

  • dLow-dose aspirin and beta-blocker use ever after diagnosis for statin use after diagnosis columns, low-dose aspirin and beta-blocker use in year before diagnosis for statin use in year before diagnosis column.