Table 2.

Univariate and multivariate analyses

Number of patientsNumber of deathsUnivariate analysisMultivariate analysisMultivariate analysis with bootstrap procedure
HR (95% CI)PHR (95% CI)P95% percentile CI
Age, y
 ≤6593841 (—)
 >6584781.243 (0.912–1.694)0.1689
Sex
 Male74651
 Female103971.310 (0.955–1.798)0.0941
PS OMS
 091801
 >076731.274 (0.927–1.751)0.1355
Primary tumor site
 Colon1201131
 Rectum57490.855 (0.610–1.196)0.3597
Timing to metastasis
 Metachronous1191111
 Synchronous54471.458 (1.035–2.054)0.0308
Metastases localization
 Liver alone68591
 Liver and other98951.816 (1.305–2.527)
 Other alone1180.686 (0.326–1.442)0.0003
Surgery of the primary tumor
 Yes1101011
 No65591.433 (1.035–1.984)0.0304
Leucocyte (×106/mL)1371221.120 (1.056–1.188)0.0002
Lymphocyte (×106/mL)1321200.795 (0.589–1.073)0.1339
LDH
 ≤350 (ULN)564911
 >350 (ULN)59582.026 (1.373–2.988)0.00041.598 (1.040–2.454)0.0323(1.039–2.628)
Log_Ang-2 (pg/mL)1771621.911 (1.492–2.448)<0.00011.587 (1.138–2.213)0.0065(1.161–2.263)

NOTE: Bold characters represent significative results.

Abbreviation: ULN, upper limit of normal.