Table 3.

Multivariate-adjusted OR and 95% CI of colorectal adenoma according to HCA estimates

MenWomen
Quartile (Q)IntakeaNbOR (95% CI)cIntakeaNbOR (95% CI)c
PhIP
 Q17.4108/1131.00 (Reference)7.550/611.00 (Reference)
 Q214.1150/1131.33 (0.91–1.93)15.046/610.74 (0.42–1.32)
 Q322.3121/1131.09 (0.74–1.60)22.567/611.08 (0.62–1.88)
 Q433.4119/1141.02 (0.69–1.50)33.477/611.43 (0.83–2.45)
Ptrend0.770.09
MeIQx
 Q11.8105/1131.00 (Reference)2.248/611.00 (Reference)
 Q23.2146/1131.33 (0.91–1.94)3.556/611.02 (0.58–1.78)
 Q34.9137/1131.26 (0.86–1.85)5.055/610.97 (0.56–1.70)
 Q47.4110/1141.01 (0.68–1.50)7.081/611.58 (0.92–2.73)
Ptrend0.970.10
MeIQ
 Q11.5118/1131.00 (Reference)1.637/611.00 (Reference)
 Q22.9143/1131.21 (0.84–1.76)2.958/611.42 (0.80–2.53)
 Q34.4114/1130.95 (0.65–1.40)4.364/611.73 (0.97–3.08)
 Q46.2123/1140.94 (0.64–1.37)6.081/612.10 (1.20–3.67)
Ptrend0.470.01
Total HCA
 Q112.3108/1131.00 (Reference)12.743/611.00 (Reference)
 Q223.4153/1131.43 (0.98–2.08)23.850/611.04 (0.58–1.86)
 Q335.8115/1131.05 (0.71–1.55)36.473/611.44 (0.83–2.51)
 Q453.6122/1141.02 (0.69–1.50)54.374/611.73 (0.99–3.01)
Ptrend0.640.03
  • aMedian (ng/d).

  • bCases/controls.

  • cAdjusted for age, screening period, smoking, alcohol consumption, body mass index, physical activity, family history of colorectal cancer, and NSAID use. Further adjusted for age at menarche, menopausal status, and current use of hormones in females.