Table 4.

Pathway-based analysis using occupational exposure interactions for possible occupational lung carcinogens

Pathway namePathway databasePathway analysis methodP
Asphalt-bitumen fumesBAD pathway—apoptosisBiocartaIGSEA<0.001
Carbon black dustDNA repairREACTOMEKGG0.0007
Glycerolipid metabolismKEGGIGSEA/KGG0.001/0.01
Coal and coke combustion fumesRibosomeKEGGIGSEA0.001
Integrin pathwayBiocarta/PIDIGSEA/KGG0.007/0.008
FAS signaling pathwaySTKE/PIDIGSEA/KGG0.001/0.02
PDGF pathwayBiocarta/BiocartaIGSEA/KGG0.004/0.036
MAPK–ERK pathwayBiocartaIGSEA/KGG0.007/0.002
ECM receptor interactionKEGGIGSEA/KGG0.002/0.02
Coal dustTNF pathwaySTKEIGSEA<0.001
Ribosomal proteinsWikiIGSEA<0.001
Fas signaling pathwaySTKE/PIDIGSEA/KGG0.004/0.018
Coal tar pitch fumesRAS pathwayGO:0007265/PIDINRICH/KGG0.003/0.001
P53 pathwayBiocartaKGG0.00005
GPCR pathwayWikiIGSEA0.001
Graphite dustLeukocyte migrationKEGGIGSEA/KGG0.008/0.009
Snare interactions in transportKEGG/ReactomeIGSEA/KGG0.016/0.03
Ribosome proteinWiki/KEGGIGSEA/KGG0.002/0.048
B-cell receptor pathwayKEGG/Sigma-AldrichIGSEA/KGG0.002/0.004
SootPhosphatidylinositol signaling systemKEGGIGSEA<0.001
Inositol phosphate metabolismKEGGIGSEA/KGG0.002/0.002
TNF pathwaySTKEIGSEA0.001
T-cell signal transductionSTKE/BiocartaIGSEA/KGG0.01/0.008
Diesel and keroseneMAPK pathwaySTKE/ReactomeIGSEA/KGG0.024/0.03
TCR pathwayBiocarta/PIDIGSEA/KGG0.024/0.03
FC Epsilon signaling pathwayKEGGIGSEA<0.001
GPCR pathwayBiocartaIGSEA<0.001
GasolineTCR pathwayBiocarta/STKEIGSEA/KGG0.013/0.057
Petroleum oil combustion fumesDNA replicationKEGG/REACTOMEIGSEA/KGG0.007/0.002
Hard-alloys dustGap junctionKEGGIGSEA/KGG<0.001/0.01
Calcium signaling pathwayKEGGIGSEA/KGG0.001/0.028
ApoptosisWiki/ReactomeIGSEA/KGG0.007/0.0009
Inorganic insulation dustRho signalingGO:0035023/ReactomeINRICH/KGG0.009/0.02
TranscriptionReactomeKGG0.00008
MAPK pathwayKEGGKGG0.00008
TCR pathwayPIDKGG0.0001
Inorganic pigments dustGPCR pathwayWikiIGSEA<0.001
Iron and compounds fumesMAPK pathwaySTKE/ReactomeIGSEA/KGG0.019/0.02
Arachidonic acid metabolismKEGGIGSEA/KGG0.015/0.04
Mild steel dustCell cycleWikiIGSEA0.001
Biosynthesis of steroidsKEGGIGSEA0.001
Stainless steel dustGPCR pathwayWikiIGSEA<0.001
VEGF pathwayBiocartaIGSEA<0.001
Wood dustAntigen processing and presentationKEGGIGSEA0.008
Hard-wood dustGPCR pathwayWiki/BiocartaIGSEA/KGG0.001/0.002
Inositol metabolismKEGGIGSEA<0.001
PPARA pathwayBiocartaKGG0.00003
Soft-wood dustAntigen processing and presentationKEGGIGSEA<0.001
Inorganic pesticideNK cell–mediated cytotoxicityKEGGINRICH0.002
T-cell activationGO:0031295/BiocartaINRICH/IGSEA0.001/<0.001
FormaldehydeMAPK signaling pathwayBiocarta/KEGGIGSEA/KGG<0.001/0.05
Cutting fluid mistIL2RB pathwayBiocartaIGSEA/KGG0.002/0.05
Inorganic acids mistPyrimidine metabolismKEGGIGSEA/KGG0.01/0.01
TranscriptionGO:0030528/ReactomeINRICH/IGSEA/KGG0.037/0.01/0.002
Tight junctionKEGG/ReactomeINRICH/KGG0.03/0.03
Lubricating oil mistMTOR signaling pathwayKEGGKGG0.0002
PI3K pathwayReactomeKGG0.00003
Regulation of autophagyKEGGIGSEA<0.001
Other mineral oil mistPyrimidine metabolismKEGGINRICH0.001
Arc welding fumesCell cycleBiocartaIGSEA<0.001
Gas welding fumesTranscriptionGO:0006350/KEGGINRICH/KGG0.02/0.0004
Animal virusesTranslationKEGGIGSEA0.005
Cell cycleKEGGIGSEA/KGG0.001/0.0001
Hedgehog signaling pathwayKEGGIGSEA/KGG0.016/0.001
WNT signalingSuperArrayIGSEA/KGG0.003/0.003
Abrasives dustTranscriptionGO:0016481/KEGGINRICH/IGSEA0.005/0.002
GTPase activityGO:0003924INRICH0.007
Adenylate cyclase pathwayReactomeKGG0.003
Plastics pyrolysis fumesOxidative phosphorylationKEGGIGSEA/KGG0.005/0.03
Xenobiotic metabolism by C450KEGGIGSEA/KGG0.01/0.04

Abbreviations: KGG, knowledge-based mining system for genome-wide genetic studies; PID, pathway interaction database; STKE, signal transduction knowledge environment.