Table 3.

Percentage of subjects exceeding 150% and 200% CPD and CO

StudyaSummaryTime 1Time 2Time 3Time 4Time 5Time 6
Percentage of subjects exceeding 200% (or 2-fold) of baseline CPD and CO
CPD
 Benowitz et al. (5)GradualBaseline0.00.00.00.05.0
 Benowitz et al. (8)Gradual0.01.90.00.00.00.0
 DonnyImmediate0.01.02.11.02.10.0
 Hatsukami et al. (6)Immediate0.00.00.00.00.00.0
 Hatsukami et al. (7)Immediate0.03.23.23.53.63.6
 Benowitz et al. (8)Usual brand0.00.00.00.00.02.0
 DonnyUsual brand0.02.010.210.210.26.1
CO
 Benowitz et al. (5)GradualBaseline0.00.00.00.00.0
 Benowitz et al. (8)Gradual1.95.78.05.93.97.5
 DonnyImmediate3.36.55.62.25.67.6
 Hatsukami et al. (6)Immediate6.710.511.49.46.26.1
 Hatsukami et al. (7)Immediate2.81.65.03.53.61.8
 Benowitz et al. (8)Usual brand4.14.06.08.04.02.0
 DonnyUsual brand6.26.50.02.14.310.4
Percentage of subjects exceeding 150% of baseline CPD and CO
CPD
 Benowitz et al. (5)GradualBaseline0.00.00.00.05.0
 Benowitz et al. (8)Gradual0.01.90.00.00.00.0
 DonnyImmediate0.01.02.11.02.10.0
 Hatsukami et al. (6)Immediate0.00.00.00.00.00.0
 Hatsukami et al. (7)Immediate0.03.23.23.53.63.6
 Benowitz et al. (8)Usual brand0.00.00.00.00.02.0
 DonnyUsual brand0.02.010.210.210.26.1
CO
 Benowitz et al. (5)GradualBaseline0.00.00.00.00.0
 Benowitz et al. (8)Gradual1.95.78.05.93.97.5
 DonnyImmediate3.36.55.62.25.67.6
 Hatsukami et al. (6)Immediate6.710.511.49.46.26.1
 Hatsukami et al. (7)Immediate2.81.65.03.53.61.8
 Benowitz et al. (8)Usual brand4.14.06.08.04.02.0
 DonnyUsual brand6.26.50.02.14.310.4
  • aBenowitz et al. (5) weekly reduction schedule (with Time 1 serving as baseline) and Benowitz et al. (8) monthly reduction schedule (with Times 5 and 6 at the lowest dose); nicotine yields were 0.8–0.9, 0.6, 0.3–0.4, 0.2, and 0.1 mg FTC; all other study time points are weekly with nicotine yields <0.1 mg. Cotinine was only assessed at baseline, weeks 2, and 6 for the immediate reduction studies.