Table 3.

Baseline characteristics of the patients involved in the multivariate analysis according to the Ang-2 level (n = 109)

Ang-2 < 5 ng/mLAng-2 ≥ 5 ng/mL
n(n = 69)(n = 40)Pb
Age, yc
 ≤655631 (45)25 (63)
 >655338 (55)15(37)0.11
Sexc
 Male4539 (57)25 (63)
 Female6430 (43)15 (37)0.54
PS OMSc
 05741 (59)16 (40)
 >05228 (41)24 (60)0.07
Primary tumor sitec
 Colon7346 (67)27 (68)
 Rectum3623 (33)13 (32)0.93
Timing to metastasisc
 Synchronous7439 (57)35 (92)
 Metachronous3229 (43)3 (8)<0.0001
Metastases localizationc
 Liver alone4328 (41)15 (37)
 Liver and other5833 (48)25 (63)
 Other alone88 (12)0 (0)0.04515
Surgery of the primary tumorc
 No7316 (24)18 (46)
 Yes3452 (76)21 (54)0.0189
Leucocyte (×106/mL)a897.3713 ± 2.39729.4180 ± 3.82690.0026
Lymphocyte (×106/mL)a851.6589 ± 0.63551.2187 ± 0.58160.0017
LDHc
 ≤350 (ULN)5243 (62)9 (23)
 >350 (ULN)5726 (38)31 (77)<0.0001
GERCOR scorec
 0 Low-risk3229 (42)3 (7)
 1 Intermediate-risk4526 (38)19 (48)
 2 High-risk3214 (20)18 (45)0.0002

NOTE: Bold characters represent significative results.

  • aPlus–minus values are means ± SD, and the unpaired t test was used for the comparison of variable among groups.

  • bP values are for the comparison between cohort set-1 and cohort set-2 populations.

  • cχ2 or Fisher's exact tests were used for the comparison of categorical variables.