Table 2.

Associations between CIMP and selected CRC risk factors by gender

Male-weighteda (n)Female-weighted (n)
CIMPb (%)Non-CIMP (%)OR (95% CI)cPCIMP (%)Non-CIMP (%)OR (95% CI)cPInteraction P (df)
Family CRC historyd
 None280 (86.4)2,534 (79.9)1.0356 (77.3)1,708 (74.6)1.0
 ≥144 (13.6)636 (20.1)0.55 (0.39–0.78)0.0007105 (22.7)580 (25.3)0.54 (0.41–0.70)0.00010.83 (1)
Smoking (pack-years)e
 090 (28.0)894 (29.0)1.0208 (44.9)1,122 (50.0)1.0
 1–1024 (7.5)456 (14.7)0.42 (0.26–0.68)0.000480 (17.4)454 (20.2)1.18 (0.87–1.61)0.30
 11–2053 (16.6)466 (15.1)1.32 (0.90–1.92)0.1653 (11.4)234 (10.4)1.13 (0.78–1.64)0.53
 21–4083 (25.8)621 (20.1)1.26 (0.90–1.76)0.1769 (14.8)263 (11.7)1.84 (1.31–2.60)0.0005
 ≥4072 (22.2)654 (21.2)0.94 (0.66–1.33)0.7354 (11.6)172 (7.7)2.07 (1.40–3.01)0.0003
 Trend1.06 (0.98–1.14)0.181.20 (1.10–1.30)0.00010.0002 (4)
Alcohol (drinks/wk)
 0103 (33.0)1,067 (35.0)1.0280 (65.9)1,260 (57.7)1.0
 1170 (54.3)1,709 (55.9)0.94 (0.72-1.23)0.65121 (28.4)803 (36.8)0.67 (0.52–0.86)0.0019
 >140 (12.8)281 (9.1)1.39 (0.92-2.09)0.1124 (5.6)122 (5.6)0.83 (0.50–1.36)0.45
 Trend1.10 (0.90-1.34)0.340.78 (0.64–0.94)0.010.15 (2)
BMI, kg/m2
 18–24.995 (29.1)737 (23.2)1.0200 (43.1)1,184 (51.7)1.0
 25–29.9147 (45.0)1,732 (54.6)0.51 (0.38–0.69)0.0001133 (28.8)636 (27.8)1.42 (1.09–1.86)0.03
 ≥3084 (25.8)703 (22.2)0.78 (0.56–1.08)0.13131 (28.2)470 (20.5)1.93 (1.09–2.56)0.0001
 Trend0.87 (0.73–1.04)0.131.39 (1.21–1.60)0.00010.0001 (2)
Physical activityf
 0–5.786 (28.1)688 (22.6)1.0146 (34.4)580 (26.7)1.0
 5.8–14.559 (19.4)616 (20.3)0.76 (0.53–1.10)0.1587 (20.5)519 (23.9)0.60 (0.44–0.83)0.002
 14.6–30.868 (22.3)776 (25.5)0.77 (0.54–1.09)0.1489 (21.0)509 (23.4)0.74 (0.54–1.02)0.070
 >30.892 (30.2)963 (31.6)0.87 (0.63–1.20)0.40102 (24.1)566 (26.0)0.74 (0.54–1.00)0.051
 Trend0.96 (0.86–1.07)0.460.92 (0.83–1.02)0.1010.71 (3)
  • aAs defined in the text, the sampling weights are the inverse of the sampling fraction which corrected for the oversampling of case probands by age, race, and family history.

  • bDefined as a PMR ≥ 10 for at least 3 of 5 genes: CACNA1G, IGF2, NEUROG1, RUNX3, and SOCS1.

  • cORs and 95% confidence limits estimated using logistic regression and controlling for age (≤50, 51–69, ≥70 years) and tumor site.

  • dThe subject reported a history of CRC in one or more first-degree relatives (parents, siblings, or children).

  • eNumber of reported cigarettes per day multiplied by the number of years of smoking.

  • fMet-hours for 10 different physical activities were summed across up to three age groups (≤30/31–49/≥50) based on subjects' age at the time of the questionnaire and the mean of the total MET-hours per week.