Table 3.

Overall mortality and breast cancer–specific mortality in relation to diabetes, hypertension, and myocardial infarction by timing and treatment for comorbidity, and by history of previous cancer, CBCSC, diagnoses 1993–2007

DiabetesHBP or hypertensionMyocardial infarction
OverallBreast cancer–specificOverallBreast cancer–specificOverallBreast cancer–specific
HRa (95% CI)HRa (95% CI)HRa (95% CI)HRa (95% CI)HRa (95% CI)HRa (95% CI)
Duration of comorbidity before breast cancer diagnosis
 No comorbidity1.001.001.001.001.001.00
 Yes comorbidity ≤5 y1.54 (1.17–2.02)1.13 (0.76–1.69)1.06 (0.89–1.27)0.91 (0.71–1.16)1.34 (0.83–2.16)b1.41 (0.62–3.23)b
 Yes comorbidity 6–14 y2.02 (1.51–2.71)1.45 (0.92–2.27)1.24 (1.03–1.49)1.03 (0.79–1.33)1.93 (1.17–3.17)2.00 (0.87–4.58)
 Yes comorbidity ≥15 y1.88 (1.38–2.57)1.81 (1.17–2.81)1.18 (0.97–1.44)0.93 (0.70–1.24)
Treated for comorbidity
 No comorbidity1.001.001.001.00
 Yes condition, not treated1.83 (1.16–2.89)2.12 (1.25–3.63)0.89 (0.58–1.36)0.80 (0.48–1.32)Not availableNot available
 Yes condition, treated1.69 (1.38–2.07)1.13 (0.82–1.55)1.13 (0.94–1.35)0.95 (0.75–1.19)
 Yes condition, treated not known2.06 (1.62–2.61)2.02 (1.39–2.93)1.24 (1.11–1.39)0.96 (0.80–1.16)
PC and comorbidity
 No PC, no comorbidity1.001.001.001.001.001.00
 No PC, yes comorbidity1.77 (1.50–2.08)1.46 (1.15–1.85)1.18 (1.07–1.30)0.95 (0.82–1.10)1.48 (1.12–1.94)1.86 (1.20–2.88)
 Yes PC, no comorbidity1.22 (1.04–1.43)1.08 (0.84–1.39)1.20 (1.00–1.45)1.15 (0.87–1.51)1.24 (1.06–1.45)1.05 (0.81–1.35)
 Yes PC, yes comorbidity3.02 (2.01–4.54)2.10 (0.98–4.86)1.67 (1.33–2.09)0.98 (0.62–1.55)3.33 (1.71–6.49)2.59 (0.63–10.57)

Abbreviation: PC, previous cancer.

  • aAdjusted for race/ethnicity, age, stage (AJCC), hormone receptor status, nodal involvement, grade, tumor size, surgery type, chemotherapy, radiotherapy, prior cancer, BMI, education, neighborhood SES, nativity, marital status, menopausal status, age at first birth, smoking, and alcohol consumption.

  • bDuration defined as number of years between diagnosis of comorbidity and diagnosis of breast cancer. For myocardial infarction, the cut points were <10 years and ≥10 years.