Table 1.

Distribution of CIMP status by center, age, and tumor location stratified by gender (unweighted n = 1,628 males/1,491 females)

Male-weightedaFemale-weighted
CIMPb (%)Non-CIMP (%)OR (95% CI)PCIMP (%)Non-CIMP (%)OR (95% CI)PInteraction P (df)
Patient agec
 ≤50 y18 (5.5)465 (14.7)1.034 (7.3)515 (22.5)1.0
 51–69 y185 (56.7)1,842 (58.1)2.76 (1.67–4.58)0.0001225 (48.5)1,277 (55.8)2.59 (1.76–3.83)0.0001
 ≥70 y124 (37.9)865 (27.3)3.35 (1.99–5.63)0.0001205 (44.2)497 (21.7)4.61 (3.09–6.88)0.0001
 Trend1.52 (1.25–1.84)0.00012.01 (1.69–2.38)0.00010.065 (2)
Tumor sited
 Proximal241 (73.8)908 (28.7)8.48 (5.97–12.10)0.0001399 (86.0)792 (34.6)9.59 (6.51–14.14)0.00010.014 (2)
 Distal48 (14.7)1,037 (32.7)1.49 (0.97–2.31)0.0735 (7.5)859 (37.5)0.84 (0.51–1.39)0.50
 Rectal38 (11.5)1,226 (38.7)1.030 (6.5)638 (27.9)1.0
BRAF (V600E)e
 Mutated148 (45.4)55 (1.8)35.7 (24.3–52.5)0.0001342 (77.3)56 (2.5)90.6 (62.4–131.5)0.00010.0011 (1)
 Not mutated178 (54.6)3,084 (98.3)1.0100 (22.7)2,196 (97.5)1.0
 Missing0332238
KRASe
 Mutated95 (34.3)814 (32.1)0.76 (0.58–1.0)0.0643 (11.3)643 (35.1)0.22 (0.16–0.32)0.0001<0.0001 (1)
 Not mutated182 (65.7)1,721 (67.9)1.0339 (88.7)1,192 (65.0)1.0
 Missing5063782455
MSI statuse
 MSI-H122 (37.5)275 (7.9)3.86 (2.86–5.20)<0.0001306 (66.1)192 (8.4)12.61 (9.56–16.6)<0.0001<0.0001 (2)
 MSI-L46 (14.1)481 (13.8)1.28 (0.90–1.82)0.1734 (7.5)299 (13.1)1.34 (0.89–2.02)0.17
 MSS158 (48.4)2,394 (68.9)1.0122 (26.4)1,792 (78.5)1.0
 Missing02226
  • aAs defined in the text, the sampling weights are the inverse of the sampling fraction that corrected for the biased sampling of case probands by age, race, and family history.

  • bDefined as a PMR ≥ 10 for at least 3 of 5 genes: CACNA1G, IGF2, NEUROG1, RUNX3, and SOCS1.

  • cLogistic regression model using proband weights and controlling for tumor site.

  • dLogistic regression model using proband weights and controlling for age (≤50, 51–69, ≥70 years).

  • eLogistic regression model using proband weights and controlling for age (≤50, 51–69, ≥70 years) and tumor site.