Table 1.

Chromosome regions with the most statistically significant linkage: mean tests and Haseman–Elston regression (in sibling pairs only)

Concordantly affected sibling pairs (n = 27)Discordantly affected sibling pairs (n = 84)Concordantly unaffected sibling pairs (n = 19)
Chromosome location (cM)Allele sharingSEPAllele sharingSEPAllele sharingSEPH–E P valuea
3 (196)0.5870.0600.0790.4150.0300.0010.5890.0550.0610.00008b
16 (83)0.4860.0680.5800.4750.0370.2520.5300.0660.3270.00010c

NOTE: The three mean tests are not adjusted for any covariates. All tests are one-sided as implemented in SIBPAL.

  • aBased on 1 million replicate permutations.

  • bHaseman–Elston regression with W4 regression (dependent variable is a weighted combination of sibpair mean-corrected squared trait sum and sibpair squared trait difference), and adjusting for date of birth (pairwise sum and absolute difference) and African ancestry proportion (pairwise absolute difference).

  • cOriginal Haseman–Elston regression (dependent variable is sibpair squared trait difference), and adjusted for date of birth (pairwise sum and absolute difference) and African ancestry proportion (pairwise absolute difference).