Table 2.

Methylation sites associated with BMI (FDR < 0.05) in the CBCS among patients with ER-positive tumors

Probe IDGeneGene descriptionCHRaIslandbCoefficientPqNormalcOverweightc,dObesec
DNMT3B_P352_RDNMT3BDNA cytosine-5 methyltransferase 3 beta isoform 220q11N0.02300.000170.0381815.5%17.3%17.6%
IGFBP6_E47_FIGFBP6Insulin-like growth factor binding protein 612q13N0.04470.000320.0381837.5%40.5%43.3%
ERCC6_P698_RERCC6Excision repair cross-complementing rodent repair deficiency, complementation group 610q11Y0.04800.000370.0381843.1%46.8%47.3%
SH3BP2_P771_ReSH3BP2SH3 domain–binding protein 24p16Y0.03240.000480.0381817.4%20.8%22.7%
PLAGL1_E68_RPLAGL1Pleiomorphic adenoma gene-like 1 isoform 16q24–25Y0.04220.000490.0381869.8%72.5%75.4%
FZD9_E458_FFZD9Frizzled 97q11Y0.05350.000960.0464049.2%50.0%55.4%
BMPR1A_E88_FBMPR1ABone morphogenetic protein receptor, type IA precursor10q22Y0.03200.001010.0464065.0%66.7%69.2%
TSG101_P257_RTSG101Tumor susceptibility gene 10111p15Y0.04000.001320.0464025.4%29.0%29.8%
RIPK4_E166_FRIPK4Receptor-interacting serine-threonine kinase 421q22Y0.01710.001330.046407.2%9.6%10.1%
Xist_seq_80_S95_ReXISTX inactive–specific transcript (non–protein-coding)Xq13N0.02990.001430.0464074.3%76.3%78.9%
TDGF1_P428_RTDGF1Teratocarcinoma-derived growth factor 13p21N0.04120.001470.0464040.7%41.8%44.6%
MCF2_P1024_RMCF2MCF.2 cell line–derived transforming sequenceXq27N0.03930.001510.0464077.6%80.6%82.3%
SPI1_E205_FSPI1Spleen focus-forming virus (SFFV) proviral integration oncogene spi111p11Y0.03720.001540.0464054.1%57.8%58.8%
SH3BP2_E18_FSH3BP2SH3 domain–binding protein 24p16N0.02840.002080.0493425.3%28.6%29.9%
ABO_E110_FABOABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1–3-galactosyltransferase)9q34Y0.03730.002250.0493415.8%18.0%20.6%
CHI3L2_P226_FCHI3L2Chitinase 3-like 2 isoform c1p13N0.03520.002270.0493474.8%75.2%74.6%
BTK_P105_FBTKBruton agammaglobulinemia tyrosine kinaseXq21–22N0.03630.002400.0493439.6%42.4%44.8%
SNURF_P78_FSNURFSNRPN upstream reading frame protein15q11–12Y0.03810.002540.0493469.5%71.0%74.3%
ARHGDIB_P148_RARHGDIBRho GDP dissociation inhibitor (GDI) beta12p12N0.03400.002550.0493444.5%45.5%47.0%
SEZ6L_P299_FSEZ6LSeizure-related 6 homolog (mouse)-like precursor22q12Y0.04820.002550.0493417.5%18.0%21.3%
PKD2_P336_RPKD2Polycystin 24q22Y0.02600.002650.0493413.1%14.6%16.5%
  • aCHR = chromsome.

  • bIsland indicates whether the probe is located in a CpG Island; N = no; Y = yes.

  • cUnadjusted % methylation; normal weight: 18.5 ≤ BMI < 25; overweight: 25 ≤ BMI < 30; obese BMI ≥ 30.

  • dOverweight individuals were not included in the regression analysis, but are included here for descriptive purposes.

  • eAssociated with BMI in overall breast tumor tissue regression analysis.