Table 1.

Baseline characteristics of patients, according to the cohort set

Overall population (N = 177)Cohort set-1 (N = 51)Cohort set-2 (N = 126)
CharacteristicsNNNPc
Age, yd51126
 ≤6517793 (53%)27 (53%)66 (52%)
 >6584 (47%)24 (47%)60 (48%)0.9461
Patient male sex, n (%)d17774 (42%)5128 (55%)12646 (37%)0.0246
PS OMSd167
 0, n (%)91 (55%)4827 (56%)11964 (54%)
 >0, n (%)76 (45%)21 (44%)55 (46%)0.7719
Primary tumor sited17751126
 Colon, n (%)120 (68%)32 (63%)88 (70%)
 Rectum, n (%)57 (32%)19 (37%)38 (30%)0.3602
Metastases localizationd17751126
 Liver and other, n (%)98 (55%)17 (33%)81 (64%)
 Liver alone, n (%)68 (39%)23 (45%)45 (36%)
 Other alone, n (%)11 (6%)11 (22%)0 (0%)0.0001
Timing of metastasesd17348125
 Synchrone, n (%)119 (69%)30 (63%)89 (71%)
 Metachrone, n (%)54 (31%)18 (37%)36 (29%)0.2688
Surgery of the primary tumor, n (%)d175110 (63%)4928 (57%)12682 (65%)0.3293
Leucocyte (×106/mL)a1378.1 ± 3.2498.1 ± 3.5888.2 ± 3.00.8926
Lymphocyte (×106/mL)a1321.5 ± 0.7451.7 ± 0.7871.4 ± 0.60.0550
LDHd1153382
 ≤350 (ULN)56 (49%)20 (61%)36 (44%)
 >350 (ULN)59 (51%)13 (39%)46 (56%)0.1050
Ang-2 (ng/mL)b1774.249 (2.683–7.153)512.793 (2.103–4.330)1264.728 (3.298–7.798)0.0001
Death eventd1775136 (71%)126126 (100%)0.0001
Median follow-up time in months 95% CI57.9 (53.1–60.3)Max time observed = 64.1
All patients were follow-up until death

NOTE: Bold characters represent significative results.

Abbreviation: ULN, upper limit of normal.

  • aPlus–minus values are means ± SD, and the unpaired t test was used for the comparison of variable among groups.

  • bMedian and interquartile range are described, and the Wilcoxon rank-sum test was used for the comparison of variable among groups.

  • cP values are for the comparison between cohort set-1 and cohort set-2 populations.

  • dχ2 or Fisher's exact tests were used for the comparison of categorical variables.